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Identification and characterization of a noncoding RNA at the mouse Pcna locus.

Authors
 Ji-Yeon Lee ; Abdul Aziz Khan ; Myoung Hee Kim ; Xinnan Wang ; Hyehyun Min 
Citation
 Molecules and Cells, Vol.33(2) : 111~116, 2012 
Journal Title
 Molecules and Cells 
ISSN
 1016-8478 
Issue Date
2012
Abstract
AK007836 encodes a noncoding RNA (ncRNA) consisting of 2 exons. Since AK007836 is located just upstream of Pcna and transcribed in the opposite direction to that of Pcna, we analyzed its expression pattern. Both ncRNA and Pcna expressions were detected in in vitro and in vivo cells, showing a positive correlation. A 177 bp region separating the first exons of Pcna and AK007836 has a bidirectional promoter activity. When the expression of ncRNA was reduced by siRNA, Pcna expression was also reduced in normal cells, but not in cancer cells. These results suggest that the ncRNA is divergently transcribed from the bidirectional promoter, positively regulating the neighboring protein-coding Pcna gene transcription, and this regulatory function is somehow disrupted in cancer cells.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/91483
DOI
10.1007/s10059-012-2164-x
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anatomy
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Link
 http://link.springer.com/article/10.1007%2Fs10059-012-2164-x
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