6 285

Cited 0 times in

Identification and characterization of a noncoding RNA at the mouse Pcna locus.

DC FieldValueLanguage
dc.contributor.author김명희-
dc.contributor.author민혜현-
dc.contributor.author이지연-
dc.date.accessioned2014-12-19T17:28:43Z-
dc.date.available2014-12-19T17:28:43Z-
dc.date.issued2012-
dc.identifier.issn1016-8478-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91483-
dc.description.abstractAK007836 encodes a noncoding RNA (ncRNA) consisting of 2 exons. Since AK007836 is located just upstream of Pcna and transcribed in the opposite direction to that of Pcna, we analyzed its expression pattern. Both ncRNA and Pcna expressions were detected in in vitro and in vivo cells, showing a positive correlation. A 177 bp region separating the first exons of Pcna and AK007836 has a bidirectional promoter activity. When the expression of ncRNA was reduced by siRNA, Pcna expression was also reduced in normal cells, but not in cancer cells. These results suggest that the ncRNA is divergently transcribed from the bidirectional promoter, positively regulating the neighboring protein-coding Pcna gene transcription, and this regulatory function is somehow disrupted in cancer cells.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfMOLECULES AND CELLS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBase Sequence-
dc.subject.MESHCarcinoma, Lewis Lung-
dc.subject.MESHFibroblasts/metabolism-
dc.subject.MESHGene Expression Regulation, Neoplastic*-
dc.subject.MESHGenetic Loci/genetics-
dc.subject.MESHMelanoma, Experimental-
dc.subject.MESHMice-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHNIH 3T3 Cells-
dc.subject.MESHProliferating Cell Nuclear Antigen/genetics*-
dc.subject.MESHPromoter Regions, Genetic/genetics-
dc.subject.MESHRNA, Small Interfering/genetics-
dc.subject.MESHRNA, Untranslated/genetics-
dc.subject.MESHRNA, Untranslated/metabolism*-
dc.subject.MESHRegulatory Sequences, Nucleic Acid/genetics-
dc.titleIdentification and characterization of a noncoding RNA at the mouse Pcna locus.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학)-
dc.contributor.googleauthorJi-Yeon Lee-
dc.contributor.googleauthorAbdul Aziz Khan-
dc.contributor.googleauthorHyehyun Min-
dc.contributor.googleauthorXinnan Wang-
dc.contributor.googleauthorMyoung Hee Kim-
dc.identifier.doi22228179-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00432-
dc.contributor.localIdA01416-
dc.contributor.localIdA03194-
dc.relation.journalcodeJ02273-
dc.identifier.eissn0219-1032-
dc.identifier.pmid22228179-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs10059-012-2164-x-
dc.subject.keywordbidirectional promoter-
dc.subject.keywordco-expression-
dc.subject.keywordgene regulation-
dc.subject.keywordnon-coding RNA-
dc.subject.keywordPcna-
dc.contributor.alternativeNameKim, Myoung Hee-
dc.contributor.alternativeNameMin, Hye Hyun-
dc.contributor.alternativeNameLee, Ji Yeon-
dc.contributor.affiliatedAuthorKim, Myoung Hee-
dc.contributor.affiliatedAuthorMin, Hye Hyun-
dc.contributor.affiliatedAuthorLee, Ji Yeon-
dc.citation.volume33-
dc.citation.number2-
dc.citation.startPage111-
dc.citation.endPage116-
dc.identifier.bibliographicCitationMOLECULES AND CELLS, Vol.33(2) : 111-116, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.