Cited 5 times in
Identification and characterization of a noncoding RNA at the mouse Pcna locus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김명희 | - |
dc.contributor.author | 민혜현 | - |
dc.contributor.author | 이지연 | - |
dc.date.accessioned | 2014-12-19T17:28:43Z | - |
dc.date.available | 2014-12-19T17:28:43Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91483 | - |
dc.description.abstract | AK007836 encodes a noncoding RNA (ncRNA) consisting of 2 exons. Since AK007836 is located just upstream of Pcna and transcribed in the opposite direction to that of Pcna, we analyzed its expression pattern. Both ncRNA and Pcna expressions were detected in in vitro and in vivo cells, showing a positive correlation. A 177 bp region separating the first exons of Pcna and AK007836 has a bidirectional promoter activity. When the expression of ncRNA was reduced by siRNA, Pcna expression was also reduced in normal cells, but not in cancer cells. These results suggest that the ncRNA is divergently transcribed from the bidirectional promoter, positively regulating the neighboring protein-coding Pcna gene transcription, and this regulatory function is somehow disrupted in cancer cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Base Sequence | - |
dc.subject.MESH | Carcinoma, Lewis Lung | - |
dc.subject.MESH | Fibroblasts/metabolism | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic* | - |
dc.subject.MESH | Genetic Loci/genetics | - |
dc.subject.MESH | Melanoma, Experimental | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | NIH 3T3 Cells | - |
dc.subject.MESH | Proliferating Cell Nuclear Antigen/genetics* | - |
dc.subject.MESH | Promoter Regions, Genetic/genetics | - |
dc.subject.MESH | RNA, Small Interfering/genetics | - |
dc.subject.MESH | RNA, Untranslated/genetics | - |
dc.subject.MESH | RNA, Untranslated/metabolism* | - |
dc.subject.MESH | Regulatory Sequences, Nucleic Acid/genetics | - |
dc.title | Identification and characterization of a noncoding RNA at the mouse Pcna locus | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anatomy (해부학) | - |
dc.contributor.googleauthor | Ji-Yeon Lee | - |
dc.contributor.googleauthor | Abdul Aziz Khan | - |
dc.contributor.googleauthor | Hyehyun Min | - |
dc.contributor.googleauthor | Xinnan Wang | - |
dc.contributor.googleauthor | Myoung Hee Kim | - |
dc.identifier.doi | 10.1007/s10059-012-2164-x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00432 | - |
dc.contributor.localId | A01416 | - |
dc.contributor.localId | A03194 | - |
dc.relation.journalcode | J02273 | - |
dc.identifier.eissn | 0219-1032 | - |
dc.identifier.pmid | 22228179 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10059-012-2164-x | - |
dc.subject.keyword | bidirectional promoter | - |
dc.subject.keyword | co-expression | - |
dc.subject.keyword | gene regulation | - |
dc.subject.keyword | non-coding RNA | - |
dc.subject.keyword | Pcna | - |
dc.contributor.alternativeName | Kim, Myoung Hee | - |
dc.contributor.alternativeName | Min, Hye Hyun | - |
dc.contributor.alternativeName | Lee, Ji Yeon | - |
dc.contributor.affiliatedAuthor | Kim, Myoung Hee | - |
dc.contributor.affiliatedAuthor | Min, Hye Hyun | - |
dc.contributor.affiliatedAuthor | Lee, Ji Yeon | - |
dc.citation.volume | 33 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 111 | - |
dc.citation.endPage | 116 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, Vol.33(2) : 111-116, 2012 | - |
dc.identifier.rimsid | 31304 | - |
dc.type.rims | ART | - |
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