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Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-γ-inducible protein 10 in a casein kinase 2-dependent manner.

 Jung-Yoon Yoo  ;  Hyo-Kyoung Choi  ;  Kyung-Chul Choi  ;  Soo-Yeon Park  ;  Ichiro Ota  ;  Jong In Yook  ;  Yoo-Hyun Lee  ;  Kunhong Kim  ;  Ho-Geun Yoon 
 Molecular Biology of the Cell, Vol.23(15) : 2943-2954, 2012 
Journal Title
 Molecular Biology of the Cell 
Issue Date
Aberrant expression of casein kinase 2 (CK2) is associated with tumor progression; however, the molecular mechanism by which CK2 modulates tumorigenesis is incompletely understood. In this paper, we show that CK2α phosphorylates the C-terminal domain of the nuclear receptor corepressor (NCoR) at Ser-2436 to stabilize the NCoR against the ubiquitin-dependent proteasomal degradation pathway. Importantly, NCoR promoted the invasion of esophageal cancer cells in a CK2-dependent manner. By using cyclic DNA microarray analysis, we identified CXCL10/IP-10 as a novel CK2α-NCoR cascade-regulated gene. The depletion of both NCoR and HDAC3 commonly derepressed IP-10 transcription, demonstrating the functional engagement of the NCoR-HDAC3 axis in IP-10 transcriptional repression. Furthermore, chromatin immunoprecipitation assays showed that c-Jun recruits NCoR-HDAC3 corepressor complexes to the (AP1 site of IP-10, leading to histone hypoacetylation and IP-10 down-regulation. Collectively these data suggest that the CK2α-NCoR cascade selectively represses the transcription of IP-10 and promotes oncogenic signaling in human esophageal cancer cells.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)
Yonsei Authors
김건홍(Kim, Kun Hong) ORCID logo https://orcid.org/0000-0001-5639-6372
유정윤(Yoo, Jung Yoon) ORCID logo https://orcid.org/0000-0001-9366-3863
윤호근(Yoon, Ho Geun) ORCID logo https://orcid.org/0000-0003-2718-3372
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