Cited 18 times in
Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-γ-inducible protein 10 in a casein kinase 2-dependent manner.
DC Field | Value | Language |
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dc.contributor.author | 김건홍 | - |
dc.contributor.author | 윤호근 | - |
dc.contributor.author | 유정윤 | - |
dc.date.accessioned | 2014-12-19T17:28:07Z | - |
dc.date.available | 2014-12-19T17:28:07Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1059-1524 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91464 | - |
dc.description.abstract | Aberrant expression of casein kinase 2 (CK2) is associated with tumor progression; however, the molecular mechanism by which CK2 modulates tumorigenesis is incompletely understood. In this paper, we show that CK2α phosphorylates the C-terminal domain of the nuclear receptor corepressor (NCoR) at Ser-2436 to stabilize the NCoR against the ubiquitin-dependent proteasomal degradation pathway. Importantly, NCoR promoted the invasion of esophageal cancer cells in a CK2-dependent manner. By using cyclic DNA microarray analysis, we identified CXCL10/IP-10 as a novel CK2α-NCoR cascade-regulated gene. The depletion of both NCoR and HDAC3 commonly derepressed IP-10 transcription, demonstrating the functional engagement of the NCoR-HDAC3 axis in IP-10 transcriptional repression. Furthermore, chromatin immunoprecipitation assays showed that c-Jun recruits NCoR-HDAC3 corepressor complexes to the (AP1 site of IP-10, leading to histone hypoacetylation and IP-10 down-regulation. Collectively these data suggest that the CK2α-NCoR cascade selectively represses the transcription of IP-10 and promotes oncogenic signaling in human esophageal cancer cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | MOLECULAR BIOLOGY OF THE CELL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-γ-inducible protein 10 in a casein kinase 2-dependent manner. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry & Molecular Biology (생화학,분자생물학) | - |
dc.contributor.googleauthor | Jung-Yoon Yoo | - |
dc.contributor.googleauthor | Hyo-Kyoung Choi | - |
dc.contributor.googleauthor | Kyung-Chul Choi | - |
dc.contributor.googleauthor | Soo-Yeon Park | - |
dc.contributor.googleauthor | Ichiro Ota | - |
dc.contributor.googleauthor | Jong In Yook | - |
dc.contributor.googleauthor | Yoo-Hyun Lee | - |
dc.contributor.googleauthor | Kunhong Kim | - |
dc.contributor.googleauthor | Ho-Geun Yoon | - |
dc.identifier.doi | 10.1091/mbc.E11-11-0947 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00289 | - |
dc.contributor.localId | A02625 | - |
dc.contributor.localId | A02502 | - |
dc.relation.journalcode | J02248 | - |
dc.identifier.eissn | 1939-4586 | - |
dc.contributor.alternativeName | Kim, Kun Hong | - |
dc.contributor.alternativeName | Yoon, Ho Geun | - |
dc.contributor.affiliatedAuthor | Kim, Kun Hong | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Geun | - |
dc.contributor.affiliatedAuthor | Yoo, Jung Yoon | - |
dc.contributor.affiliatedAuthor | 유정윤 | - |
dc.citation.volume | 23 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 2943 | - |
dc.citation.endPage | 2954 | - |
dc.identifier.bibliographicCitation | MOLECULAR BIOLOGY OF THE CELL, Vol.23(15) : 2943-2954, 2012 | - |
dc.identifier.rimsid | 31297 | - |
dc.type.rims | ART | - |
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