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Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-γ-inducible protein 10 in a casein kinase 2-dependent manner.

DC FieldValueLanguage
dc.contributor.author김건홍-
dc.contributor.author윤호근-
dc.contributor.author유정윤-
dc.date.accessioned2014-12-19T17:28:07Z-
dc.date.available2014-12-19T17:28:07Z-
dc.date.issued2012-
dc.identifier.issn1059-1524-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91464-
dc.description.abstractAberrant expression of casein kinase 2 (CK2) is associated with tumor progression; however, the molecular mechanism by which CK2 modulates tumorigenesis is incompletely understood. In this paper, we show that CK2α phosphorylates the C-terminal domain of the nuclear receptor corepressor (NCoR) at Ser-2436 to stabilize the NCoR against the ubiquitin-dependent proteasomal degradation pathway. Importantly, NCoR promoted the invasion of esophageal cancer cells in a CK2-dependent manner. By using cyclic DNA microarray analysis, we identified CXCL10/IP-10 as a novel CK2α-NCoR cascade-regulated gene. The depletion of both NCoR and HDAC3 commonly derepressed IP-10 transcription, demonstrating the functional engagement of the NCoR-HDAC3 axis in IP-10 transcriptional repression. Furthermore, chromatin immunoprecipitation assays showed that c-Jun recruits NCoR-HDAC3 corepressor complexes to the (AP1 site of IP-10, leading to histone hypoacetylation and IP-10 down-regulation. Collectively these data suggest that the CK2α-NCoR cascade selectively represses the transcription of IP-10 and promotes oncogenic signaling in human esophageal cancer cells.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfMOLECULAR BIOLOGY OF THE CELL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleNuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-γ-inducible protein 10 in a casein kinase 2-dependent manner.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry & Molecular Biology (생화학,분자생물학)-
dc.contributor.googleauthorJung-Yoon Yoo-
dc.contributor.googleauthorHyo-Kyoung Choi-
dc.contributor.googleauthorKyung-Chul Choi-
dc.contributor.googleauthorSoo-Yeon Park-
dc.contributor.googleauthorIchiro Ota-
dc.contributor.googleauthorJong In Yook-
dc.contributor.googleauthorYoo-Hyun Lee-
dc.contributor.googleauthorKunhong Kim-
dc.contributor.googleauthorHo-Geun Yoon-
dc.identifier.doi10.1091/mbc.E11-11-0947-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00289-
dc.contributor.localIdA02625-
dc.contributor.localIdA02502-
dc.relation.journalcodeJ02248-
dc.identifier.eissn1939-4586-
dc.contributor.alternativeNameKim, Kun Hong-
dc.contributor.alternativeNameYoon, Ho Geun-
dc.contributor.affiliatedAuthorKim, Kun Hong-
dc.contributor.affiliatedAuthorYoon, Ho Geun-
dc.contributor.affiliatedAuthorYoo, Jung Yoon-
dc.contributor.affiliatedAuthor유정윤-
dc.citation.volume23-
dc.citation.number15-
dc.citation.startPage2943-
dc.citation.endPage2954-
dc.identifier.bibliographicCitationMOLECULAR BIOLOGY OF THE CELL, Vol.23(15) : 2943-2954, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

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