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Physicochemical characterizations of amphiphilic block copolymers with different MWs and micelles for development of anticancer drug nanocarriers

 Jeong Min Yun  ;  So-young Park  ;  Eun Sung Lee  ;  Yu Seok Youn  ;  Ga Young Park  ;  Chaemin Lim  ;  Beom-Jin Lee  ;  Ho-Taek Song  ;  Young Taik Oh  ;  Kyung Teak Oh 
 MACROMOLECULAR RESEARCH, Vol.20(9) : 944-953, 2012 
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amphiphilic block copolymer ; polymeric micelles ; correlation equation ; PLA-b-mPEG ; nano-sized drug carrier ; anticancer drugs
Biocompatible polymers have been of considerable interest in developing drug delivery systems (DDSs). However, physicochemical characterizations of the polymers and DDSs had been limited because of the difficulty in obtaining the same synthesized copolymers and achieving a similar drug loading ability with the differing properties of the drugs. Therefore, a correlational study of the relationships between copolymers and DDSs was required to estimate the properties of the DDSs and to develop optimal systems of delivery depending on the drug. In this study, we presented several relationship correlation equations of physicochemical properties and copolymers according to their molecular weights (MWs) using amphiphilic block copolymers composed of poly(L-lactide)-block-methoxy-poly(ethylene glycol) (PLA-b-mPEG). The PLA-b-mPEG was characterized by nuclear magnetic resonance and gel permeation chromatography, and the critical micelle concentration (CMC), sizes, and drug loading capacity (DLC) of the self-assembling micelles from the copolymers with different MWs were all measured. The increase in MW of the PLA led to a decrease in CMC and DLC with an increase of the particle sizes. The relationship between the MW of the PLA and the physicochemical properties of the micelles demonstrated a good correlation, which provides excellent information for the use in the development of tailor-made DDSs based on copolymers pursuing optimal particle size, DLC, CMC, and so on.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Song, Ho Taek(송호택) ORCID logo https://orcid.org/0000-0002-6655-2575
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
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