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A case of isolated metastatic hepatocellular carcinoma arising from the pelvic bone

 Kyu Sik Jung  ;  Kyeong Hye Park  ;  Young Eun Chon  ;  Sa Ra Lee  ;  Young Nyun Park  ;  Do Yun Lee  ;  Jin Sil Seong  ;  Jun Yong Park 
 Korean Journal of Hepatology (대한간학회지), Vol.18(1) : 89-93, 2012 
Journal Title
 Korean Journal of Hepatology (대한간학회지) 
Issue Date
Aged ; Bone Neoplasms/diagnosis* ; Bone Neoplasms/pathology* ; Bone Neoplasms/radiotherapy ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/pathology* ; Carcinoma, Hepatocellular/secondary* ; Chemoembolization, Therapeutic ; Combined Modality Therapy ; Glypicans/metabolism ; Humans ; Keratin-1/metabolism ; Keratin-3/metabolism ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology* ; Liver Neoplasms/secondary* ; Magnetic Resonance Imaging ; Male ; Paraffin/metabolism ; Pelvic Bones/diagnostic imaging ; Pelvic Bones/pathology* ; Positron-Emission Tomography ; Tomography, X-Ray Computed
Hepatocellular carcinoma ; Metastasis ; Pelvic bone ; Radiotherapy ; Transarterial chemoembolization
Reports of metastatic hepatocellular carcinoma (HCC) without a primary liver tumor are rare. Here we present a case of isolated HCC that had metastasized to the pelvic bone without a primary focus. A 73-year-old man presented with severe back and right-leg pain. Radiological examinations, including computed tomography (CT) and magnetic resonance imaging (MRI), revealed a huge mass on the pelvic bone (13×10 cm). He underwent an incisional biopsy, and the results of the subsequent histological examination were consistent with metastatic hepatocellular carcinoma. The tumor cells were positive for cytokeratin (AE1/AE3), hepatocyte paraffin 1, and glypican-3, and negative for CD56, chromogranin A, and synaptophysin on immunohistochemical staining. Examination of the liver by CT, MRI, positron-emission tomography scan, and angiography produced no evidence of a primary tumor. Radiotherapy and transarterial chemoembolization were performed on the pelvic bone, followed by systemic chemotherapy. These combination treatments resulted in tumor regression with necrotic changes. However, multiple lung metastases developed 1 year after the treatment, and the patient was treated with additional systemic chemotherapy
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1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Kyeong Hye(박경혜)
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Lee, Do Yun(이도연)
Chon, Young Eun(전영은)
Jung, Kyu Sik(정규식)
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