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Clinical outcomes and prognosis of recurrent thymoma management

 Bae, Mi Kyung  ;  Byun, Chun Sung  ;  Lee, Chang Young  ;  Lee, Jin Gu  ;  Park, In Kyu  ;  Kim, Dae Joon  ;  Yang, Woo Ick  ;  Chung, Kyung Young 
 JOURNAL OF THORACIC ONCOLOGY, Vol.7(8) : 1304-1314, 2012 
Journal Title
Issue Date
Adult ; Aged ; Combined Modality Therapy ; Disease Management* ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/mortality* ; Neoplasm Recurrence, Local/therapy* ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Survival Rate ; Thymoma/mortality* ; Thymoma/therapy* ; Thymus Neoplasms/mortality* ; Thymus Neoplasms/therapy* ; World Health Organization
Thymoma ; Recurrence ; Management ; Outcomes
INTRODUCTION: Clinical outcomes and prognosis of recurrent thymoma are not well known because of its rarity and indolent clinical course. This study was designed to determine the clinical outcomes and prognosis of recurrent thymoma. METHODS: Between 1986 and 2009, 41 of 305 patients who underwent resection for thymoma had recurrence. We reviewed those patients retrospectively. RESULTS: Of 15 patients who underwent re-resection for recurrent thymoma, 13 patients (87%) achieved complete re-resection. Of 26 patients who did not undergo re-resection, 11 patients received chemotherapy, five received chemoradiotherapy, one received another treatment, and nine patients did not receive any treatment. World Health Organization histological types AB or B1 and complete re-resection were positive prognostic factors. The complete re-resection group had better survival after recurrence than the non/incomplete re-resection group (5-year survival rate: 90.9% versus 44.7%, p = 0.014). The complete re-resection group had comparable survival after initial resection of thymoma to the patients without recurrence (5-year, 10-year survival: 91.7%, 91.7% versus 90.7%, 86.5%, p = 0.618) and better survival compared with the non/incomplete re-resection group (5-year, 10-year survival: 91.7%, 91.7% versus 81.6%, 56.7%, p = 0.018). CONCLUSIONS: World Health Organization histologic types AB or B1 and complete re-resection are favorable prognostic factors of recurrent thymoma. In particular, complete re-resection of recurrent thymoma contributes to better survival than other management. Therefore, we suggest that long-term surveillance extended at least 20 years may be essential for early detection of recurrence to increase the chance of complete re-resection of recurrent thymoma.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae Joon(김대준)
Bae, Mi Kyung(배미경)
Byun, Chun Sung(변천성)
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Lee, Jin Gu(이진구)
Lee, Chang Young(이창영)
Chung, Kyung Young(정경영)
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