3 212

Cited 0 times in

Anti-obesity effect of a standardised ethanol extract from Curcuma longa L. fermented with Aspergillus oryzae in ob/ob mice and primary mouse adipocytes

Authors
 in-Nyoung Ho  ;  Ja Young Jang  ;  Ho-Geun Yoon  ;  Yongjae Kim  ;  Sunoh Kim  ;  Woojin Jun  ;  Jeongmin Lee 
Citation
 JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, Vol.92(9) : 1833-1840, 2012 
Journal Title
 JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 
ISSN
 0022-5142 
Issue Date
2012
MeSH
Adipocytes/drug effects* ; Adipocytes/metabolism ; Adiponectin/blood ; Adipose Tissue/metabolism* ; Animals ; Aspergillus oryzae/metabolism ; Carrier Proteins/metabolism ; Cholesterol/metabolism ; Cholesterol, HDL/metabolism ; Curcuma* ; Dietary Supplements ; Disease Models, Animal ; Fermentation ; Glycerol/metabolism ; Hypolipidemic Agents/pharmacology ; Hypolipidemic Agents/therapeutic use ; Lipid Metabolism/drug effects* ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Obesity/drug therapy* ; Obesity/genetics ; Obesity/metabolism ; Perilipin-1 ; Phosphoproteins/metabolism ; Phytotherapy* ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; RNA, Messenger/metabolism ; Reference Standards ; Sterol Esterase/metabolism ; Triglycerides/metabolism ; Weight Gain/drug effects*
Keywords
Curcuma Longa L. ; C57BL/6J ob /ob mouse ; primary mouse adipocytes ; HSL ; PKA ; lipolysis
Abstract
BACKGROUND: We examined the anti-obesity effect of fermented Curcuma longa L. (turmeric) standardised ethanol extract (FTE) in the C57BL/6J ob/ob mouse model. Mice were fed a chow diet containing FTE (0, 200, or 500 mg kg⁻¹ body weight) for 9 weeks. RESULTS: Supplementation with FTE significantly reduced body weight gain and retroperitoneal and epididymal adipose tissue weights compared to the ob/ob control group. Additionally, total cholesterol and triglyceride levels in serum and liver were significantly decreased in FTE-200 and FTE-500 groups when compared to those of the ob/ob control group, whereas the high-density lipoprotein-cholesterol level was significantly increased. The levels of serum adiponectin as well as mRNA expression of lipases, such as hormone sensitive lipase and adipose triglyceride lipase, were clearly increased. In primary adipocytes of C57BL/6J mice, FTE treatment caused a significant increase glycerol release and hormone sensitive lipase levels and decreased perilipin A levels. CONCLUSION: These results suggest that supplementation of FTE has potent anti-obesity effects by controlling body weight, fat mass, serum lipids, and hepatic lipids. Moreover, FTE could be considered a potential resource for the treatment of obesity through its promotion of lipolysis via the protein kinase A pathway.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jsfa.5592/abstract
DOI
22278718
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91168
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse