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Anti-obesity effect of a standardised ethanol extract from Curcuma longa L. fermented with Aspergillus oryzae in ob/ob mice and primary mouse adipocytes
DC Field | Value | Language |
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dc.contributor.author | 윤호근 | - |
dc.date.accessioned | 2014-12-19T17:18:31Z | - |
dc.date.available | 2014-12-19T17:18:31Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0022-5142 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91168 | - |
dc.description.abstract | BACKGROUND: We examined the anti-obesity effect of fermented Curcuma longa L. (turmeric) standardised ethanol extract (FTE) in the C57BL/6J ob/ob mouse model. Mice were fed a chow diet containing FTE (0, 200, or 500 mg kg⁻¹ body weight) for 9 weeks. RESULTS: Supplementation with FTE significantly reduced body weight gain and retroperitoneal and epididymal adipose tissue weights compared to the ob/ob control group. Additionally, total cholesterol and triglyceride levels in serum and liver were significantly decreased in FTE-200 and FTE-500 groups when compared to those of the ob/ob control group, whereas the high-density lipoprotein-cholesterol level was significantly increased. The levels of serum adiponectin as well as mRNA expression of lipases, such as hormone sensitive lipase and adipose triglyceride lipase, were clearly increased. In primary adipocytes of C57BL/6J mice, FTE treatment caused a significant increase glycerol release and hormone sensitive lipase levels and decreased perilipin A levels. CONCLUSION: These results suggest that supplementation of FTE has potent anti-obesity effects by controlling body weight, fat mass, serum lipids, and hepatic lipids. Moreover, FTE could be considered a potential resource for the treatment of obesity through its promotion of lipolysis via the protein kinase A pathway. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adipocytes/drug effects* | - |
dc.subject.MESH | Adipocytes/metabolism | - |
dc.subject.MESH | Adiponectin/blood | - |
dc.subject.MESH | Adipose Tissue/metabolism* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Aspergillus oryzae/metabolism | - |
dc.subject.MESH | Carrier Proteins/metabolism | - |
dc.subject.MESH | Cholesterol/metabolism | - |
dc.subject.MESH | Cholesterol, HDL/metabolism | - |
dc.subject.MESH | Curcuma* | - |
dc.subject.MESH | Dietary Supplements | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Fermentation | - |
dc.subject.MESH | Glycerol/metabolism | - |
dc.subject.MESH | Hypolipidemic Agents/pharmacology | - |
dc.subject.MESH | Hypolipidemic Agents/therapeutic use | - |
dc.subject.MESH | Lipid Metabolism/drug effects* | - |
dc.subject.MESH | Liver/drug effects | - |
dc.subject.MESH | Liver/metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mice, Obese | - |
dc.subject.MESH | Obesity/drug therapy* | - |
dc.subject.MESH | Obesity/genetics | - |
dc.subject.MESH | Obesity/metabolism | - |
dc.subject.MESH | Perilipin-1 | - |
dc.subject.MESH | Phosphoproteins/metabolism | - |
dc.subject.MESH | Phytotherapy* | - |
dc.subject.MESH | Plant Extracts/pharmacology | - |
dc.subject.MESH | Plant Extracts/therapeutic use | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Reference Standards | - |
dc.subject.MESH | Sterol Esterase/metabolism | - |
dc.subject.MESH | Triglycerides/metabolism | - |
dc.subject.MESH | Weight Gain/drug effects* | - |
dc.title | Anti-obesity effect of a standardised ethanol extract from Curcuma longa L. fermented with Aspergillus oryzae in ob/ob mice and primary mouse adipocytes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry & Molecular Biology (생화학,분자생물학) | - |
dc.contributor.googleauthor | in-Nyoung Ho | - |
dc.contributor.googleauthor | Ja Young Jang | - |
dc.contributor.googleauthor | Ho-Geun Yoon | - |
dc.contributor.googleauthor | Yongjae Kim | - |
dc.contributor.googleauthor | Sunoh Kim | - |
dc.contributor.googleauthor | Woojin Jun | - |
dc.contributor.googleauthor | Jeongmin Lee | - |
dc.identifier.doi | 22278718 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02625 | - |
dc.relation.journalcode | J01901 | - |
dc.identifier.eissn | 1097-0010 | - |
dc.identifier.pmid | 22278718 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/jsfa.5592/abstract | - |
dc.subject.keyword | Curcuma Longa L. | - |
dc.subject.keyword | C57BL/6J ob /ob mouse | - |
dc.subject.keyword | primary mouse adipocytes | - |
dc.subject.keyword | HSL | - |
dc.subject.keyword | PKA | - |
dc.subject.keyword | lipolysis | - |
dc.contributor.alternativeName | Yoon, Ho Geun | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Geun | - |
dc.citation.volume | 92 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1833 | - |
dc.citation.endPage | 1840 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, Vol.92(9) : 1833-1840, 2012 | - |
dc.identifier.rimsid | 33961 | - |
dc.type.rims | ART | - |
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