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Dysgraphia in Korean patients with Alzheimer's disease as a manifestation of bilateral hemispheric dysfunction

Authors
 Ji Hye Yoon  ;  HyangHee Kim  ;  Sang Won Seo  ;  Juhee Chin  ;  Jung-Hyun Kim  ;  Kyung-Han Lee  ;  Yong Wook Kim  ;  Eun Sook Park  ;  Mee Kyung Suh  ;  Duk L. Na 
Citation
 JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol.320(1-2) : 72-78, 2012 
Journal Title
JOURNAL OF THE NEUROLOGICAL SCIENCES
ISSN
 0022-510X 
Issue Date
2012
MeSH
Aged ; Aged, 80 and over ; Agraphia/complications ; Agraphia/diagnostic imaging ; Agraphia/physiopathology* ; Alzheimer Disease/complications ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/physiopathology* ; Asian Continental Ancestry Group/psychology ; Case-Control Studies ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/physiopathology* ; Female ; Fluorodeoxyglucose F18 ; Functional Neuroimaging/methods* ; Functional Neuroimaging/statistics & numerical data ; Humans ; Male ; Middle Aged ; Neuropsychological Tests/statistics & numerical data ; Positron-Emission Tomography/methods ; Positron-Emission Tomography/statistics & numerical data ; Psychomotor Performance/physiology ; Radiopharmaceuticals
Keywords
Hangul ; Writing ; Dysgraphia ; Linguistic ; Nonlinguistic ; Visuospatial ; Alzheimer's disease ; PET
Abstract
BACKGROUND: In writing, linguistic (i.e., spelling) and nonlinguistic (i.e., arranging strokes or letters) functions are processed by the left and right hemispheres, respectively. The configuration of Korean alphabet, 'Hangul' invokes nonlinguistic, visuospatial functions that other writing systems use less extensively. Patients with Alzheimer's disease (AD) have bilateral involvement of temporoparietal-frontal areas that are responsible for processing language and visuospatial functions.

OBJECTIVES: The aim of this study was to examine the nature of Hangul writing dysfunction, which may be associated with bilateral hemispheric impairments in AD.

METHODS: A sample of 75 patients with AD and 20 healthy controls (HC) performed a Hangul writing task. Neuroimaging positron emission tomography (PET) data of 22 patients were utilized to measure the regional brain glucose metabolism associated with Hangul writing.

RESULTS: The writing performance of the AD group was significantly reduced and different types of errors were observed as the disease got worse. Glucose hypometabolism correlated with Hangul writing impairment was located in the right occipitotemporal lobe and left temporoparietal lobe.

CONCLUSIONS: The PET findings demonstrate that impairment in Hangul writing performance in Korean AD patients is closely related to a functional decline in both the right and left hemispheres. The study provides a unique contribution to the knowledge of dysgraphia in a non-alphabetical writing system as well as the underlying neuropathology of dysgraphic features in such languages.
Full Text
http://www.sciencedirect.com/science/article/pii/S0022510X12003280
DOI
22809738
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Wook(김용욱) ORCID logo https://orcid.org/0000-0002-5234-2454
Kim, Hyang Hee(김향희) ORCID logo https://orcid.org/0000-0003-4949-2512
Park, Eun Sook(박은숙) ORCID logo https://orcid.org/0000-0002-9144-3063
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91166
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