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Dysgraphia in Korean patients with Alzheimer's disease as a manifestation of bilateral hemispheric dysfunction

DC Field Value Language
dc.contributor.author김용욱-
dc.contributor.author김향희-
dc.contributor.author박은숙-
dc.date.accessioned2014-12-19T17:18:26Z-
dc.date.available2014-12-19T17:18:26Z-
dc.date.issued2012-
dc.identifier.issn0022-510X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91166-
dc.description.abstractBACKGROUND: In writing, linguistic (i.e., spelling) and nonlinguistic (i.e., arranging strokes or letters) functions are processed by the left and right hemispheres, respectively. The configuration of Korean alphabet, 'Hangul' invokes nonlinguistic, visuospatial functions that other writing systems use less extensively. Patients with Alzheimer's disease (AD) have bilateral involvement of temporoparietal-frontal areas that are responsible for processing language and visuospatial functions. OBJECTIVES: The aim of this study was to examine the nature of Hangul writing dysfunction, which may be associated with bilateral hemispheric impairments in AD. METHODS: A sample of 75 patients with AD and 20 healthy controls (HC) performed a Hangul writing task. Neuroimaging positron emission tomography (PET) data of 22 patients were utilized to measure the regional brain glucose metabolism associated with Hangul writing. RESULTS: The writing performance of the AD group was significantly reduced and different types of errors were observed as the disease got worse. Glucose hypometabolism correlated with Hangul writing impairment was located in the right occipitotemporal lobe and left temporoparietal lobe. CONCLUSIONS: The PET findings demonstrate that impairment in Hangul writing performance in Korean AD patients is closely related to a functional decline in both the right and left hemispheres. The study provides a unique contribution to the knowledge of dysgraphia in a non-alphabetical writing system as well as the underlying neuropathology of dysgraphic features in such languages.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF THE NEUROLOGICAL SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAgraphia/complications-
dc.subject.MESHAgraphia/diagnostic imaging-
dc.subject.MESHAgraphia/physiopathology*-
dc.subject.MESHAlzheimer Disease/complications-
dc.subject.MESHAlzheimer Disease/diagnostic imaging-
dc.subject.MESHAlzheimer Disease/physiopathology*-
dc.subject.MESHAsian Continental Ancestry Group/psychology-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCerebral Cortex/diagnostic imaging-
dc.subject.MESHCerebral Cortex/physiopathology*-
dc.subject.MESHFemale-
dc.subject.MESHFluorodeoxyglucose F18-
dc.subject.MESHFunctional Neuroimaging/methods*-
dc.subject.MESHFunctional Neuroimaging/statistics & numerical data-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeuropsychological Tests/statistics & numerical data-
dc.subject.MESHPositron-Emission Tomography/methods-
dc.subject.MESHPositron-Emission Tomography/statistics & numerical data-
dc.subject.MESHPsychomotor Performance/physiology-
dc.subject.MESHRadiopharmaceuticals-
dc.titleDysgraphia in Korean patients with Alzheimer's disease as a manifestation of bilateral hemispheric dysfunction-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Rehabilitation Medicine (재활의학)-
dc.contributor.googleauthorJi Hye Yoon-
dc.contributor.googleauthorHyangHee Kim-
dc.contributor.googleauthorSang Won Seo-
dc.contributor.googleauthorJuhee Chin-
dc.contributor.googleauthorJung-Hyun Kim-
dc.contributor.googleauthorKyung-Han Lee-
dc.contributor.googleauthorYong Wook Kim-
dc.contributor.googleauthorEun Sook Park-
dc.contributor.googleauthorMee Kyung Suh-
dc.contributor.googleauthorDuk L. Na-
dc.identifier.doi22809738-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00750-
dc.contributor.localIdA01107-
dc.contributor.localIdA01611-
dc.relation.journalcodeJ01897-
dc.identifier.eissn1878-5883-
dc.identifier.pmid22809738-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0022510X12003280-
dc.subject.keywordHangul-
dc.subject.keywordWriting-
dc.subject.keywordDysgraphia-
dc.subject.keywordLinguistic-
dc.subject.keywordNonlinguistic-
dc.subject.keywordVisuospatial-
dc.subject.keywordAlzheimer's disease-
dc.subject.keywordPET-
dc.contributor.alternativeNameKim, Yong Wook-
dc.contributor.alternativeNameKim, Hyang Hee-
dc.contributor.alternativeNamePark, Eun Sook-
dc.contributor.affiliatedAuthorKim, Yong Wook-
dc.contributor.affiliatedAuthorKim, Hyang Hee-
dc.contributor.affiliatedAuthorPark, Eun Sook-
dc.citation.volume320-
dc.citation.number1-2-
dc.citation.startPage72-
dc.citation.endPage78-
dc.identifier.bibliographicCitationJOURNAL OF THE NEUROLOGICAL SCIENCES, Vol.320(1-2) : 72-78, 2012-
dc.identifier.rimsid33959-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers

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