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Ginkgo biloba Extract and Bilberry Anthocyanins Improve Visual Function in Patients with Normal Tension Glaucoma

Authors
 Seong Hee Shim  ;  Joon Mo Kim  ;  Chul Young Choi  ;  Chan Yun Kim  ;  Ki Ho Park 
Citation
 JOURNAL OF MEDICINAL FOOD, Vol.15(9) : 818-823, 2012 
Journal Title
 JOURNAL OF MEDICINAL FOOD 
ISSN
 1096-620X 
Issue Date
2012
MeSH
Adult ; Aged ; Aged, 80 and over ; Anthocyanins/therapeutic use* ; Antioxidants/therapeutic use ; Dietary Supplements* ; Female ; Follow-Up Studies ; Ginkgo biloba/chemistry* ; Humans ; Low Tension Glaucoma/diet therapy* ; Low Tension Glaucoma/physiopathology ; Male ; Middle Aged ; Phytotherapy ; Plant Extracts/therapeutic use* ; Plant Leaves/chemistry ; Retrospective Studies ; Vaccinium myrtillus/chemistry* ; Visual Acuity ; Visual Fields ; Visual Pathways/physiopathology* ; Young Adult
Keywords
Adult ; Aged ; Aged, 80 and over ; Anthocyanins/therapeutic use* ; Antioxidants/therapeutic use ; Dietary Supplements* ; Female ; Follow-Up Studies ; Ginkgo biloba/chemistry* ; Humans ; Low Tension Glaucoma/diet therapy* ; Low Tension Glaucoma/physiopathology ; Male ; Middle Aged ; Phytotherapy ; Plant Extracts/therapeutic use* ; Plant Leaves/chemistry ; Retrospective Studies ; Vaccinium myrtillus/chemistry* ; Visual Acuity ; Visual Fields ; Visual Pathways/physiopathology* ; Young Adult
Abstract
Ginkgo biloba extract (GBE) and anthocyanins are considered beneficial for various vascular diseases. This study was performed to evaluate the effect of GBE and anthocyanins on visual function in patients with normal tension glaucoma (NTG) based on the vascular theory of mechanisms of glaucomatous optic nerve damage. Retrospective analysis was carried out by a chart review of 332 subjects (209 men and 123 women) who were treated with anthocyanins (n=132), GBE (n=103), or no medication (control, n=97). Humphrey Visual Field (HVF) test, logarithm of the minimal angle of resolution best-corrected visual acuity (logMAR BCVA), intraocular pressure, blood pressure, and fasting blood glucose were determined before and after treatment. Complete ocular and systemic examinations were performed. The mean follow-up duration was 23.82±9.84 (range, 12–59) months; the mean anthocyanin treatment duration was 24.32±10.43 (range, 6–53) months, and the mean GBE treatment duration was 23.81±10.36 months (range, 6–59) months. After anthocyanin treatment, the mean BCVA for all eyes improved from 0.16 (±0.34) to 0.11 (±0.18) logMAR units (P=.008), and HVF mean deviation improved from −6.44 (±7.05) to −5.34 (±6.42) (P=.001). After GBE treatment, HVF mean deviation improved from −5.25 (±6.13) to −4.31 (±5.60) (P=.002). A generalized linear model demonstrated that the final BCVA was not affected by demographic differences among the groups. These results suggest that anthocyanins and GBE may be helpful in improving visual function in some individuals with NTG.
Files in This Item:
T201205956.pdf Download
DOI
22870951
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90964
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