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Quantitative evaluation of liver cirrhosis using T1 relaxation time with 3 tesla MRI before and after oxygen inhalation

 Kyung Ah Kim  ;  Mi-Suk Park  ;  In-Seong Kim  ;  Berthold Kiefer  ;  Woo-Suk Chung  ;  Myeong-Jin Kim  ;  Ki Whang Kim 
 Journal of Magnetic Resonance Imaging, Vol.36(2) : 405-410, 2012 
Journal Title
 Journal of Magnetic Resonance Imaging 
Issue Date
Administration, Inhalation ; Adult ; Aged ; Contrast Media/administration & dosage ; Female ; Humans ; Liver/drug effects ; Liver/physiopathology* ; Liver Cirrhosis/pathology* ; Liver Cirrhosis/physiopathology* ; Magnetic Resonance Imaging/methods* ; Male ; Middle Aged ; Oxygen/administration & dosage*
magnetic resonance imaging ; T1 relaxationtime ; liver cirrhosis ; oxygenation
PURPOSE: To quantify liver T1 relaxation times before and after oxygen inhalation in patients with and without liver cirrhosis using a 3 Tesla (T) MRI. MATERIALS AND METHODS: Institutional Review Board approval and written informed consent were obtained. Ninety-two noncirrhotic patients and 87 patients with hepatitis B viral liver cirrhosis (72 Child-Pugh class A and 15 Child-Pugh class B or C) underwent MRI with a 3.0T system before and after the supply of 100% oxygen at a rate of 15 L/min by means of a nonrebreather ventilation mask for 3 min. T1 maps were acquired using three-dimensional spoiled gradient echo sequences with two different flip angles (2° and 14°) and a fixed TR/TE (2.54 ms/0.95 ms). Liver T1 values were obtained using a T1 processing tool (MapIT software). The mean baseline T1 values of three groups (control, Child-Pugh class A, and Child-Pugh class B/C) were compared using an analysis of variance test. Liver T1 value before and after oxygenation was compared using a paired t-test for each group. RESULTS: The baseline liver T1 value was significantly higher in the control group (941 ± 136 ms) than in Child-Pugh A (858 ± 143 ms) and Child-Pugh B/C (783 ± 164 ms) group (P < 0.001 and P < 0.0001). The reduction in the liver T1 value after oxygen inhalation was significant in the control group (P = 0.012) but not significant in Child-Pugh class A (P = 0.079) and Child-Pugh class B/C (P = 0.752). CONCLUSION: The baseline liver T1 relaxation time was significantly different between the patients with and without liver cirrhosis. The shortening effect of oxygen on the liver T1 value was significant in the control group but not in the cirrhotic patients.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Ah(김경아)
Kim, Ki Whang(김기황)
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Chung, Woo Seok(정우석)
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