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Detection of liver metastases using gadoxetic-enhanced dynamic and 10- and 20-minute delayed phase MR imaging

Authors
 Hyeon Tae Jeong  ;  Myeong-Jin Kim  ;  Mi-Suk Park  ;  Jin-Young Choi  ;  Jin Sub Choi  ;  Kyung Sik Kim  ;  Gi Hong Choi  ;  Sang-Joon Shin 
Citation
 JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol.35(3) : 635-643, 2012 
Journal Title
JOURNAL OF MAGNETIC RESONANCE IMAGING
ISSN
 1053-1807 
Issue Date
2012
MeSH
Analysis of Variance ; Combined Modality Therapy ; Contrast Media* ; Diagnosis, Differential ; Female ; Gadolinium DTPA* ; Humans ; Image Interpretation, Computer-Assisted/methods* ; Liver Neoplasms/diagnosis* ; Liver Neoplasms/drug therapy ; Liver Neoplasms/secondary* ; Liver Neoplasms/surgery ; Male ; Middle Aged ; ROC Curve ; Retrospective Studies ; Sensitivity and Specificity ; Tomography, X-Ray Computed
Keywords
liver neoplasm ; diagnosis ; diagnostic accu-racy ; magnetic resonance imaging (MRI) ; liver specificcontrast agents
Abstract
PURPOSE: To assess the incremental value of hepatobiliary phase images in gadoxetate disodium-enhanced magnetic resonance imaging (MRI), and to compare diagnostic accuracy and lesion conspicuity on 10- and 20-minute delayed images for preoperative detection of hepatic metastases with subgroup analysis according to size and history of chemotherapy.

MATERIALS AND METHODS: Forty-six patients with 107 metastases who underwent surgery after gadoxetate disodium-enhanced MRI were evaluated. Four observers independently interpreted three sets: dynamic set comprising precontrast T1-, T2-weighted, and dynamic images; 10-minute set comprising dynamic set and 10-minute delayed; 20-minute set comprising 10-minute set and 20-minute delayed. Diagnostic accuracy was compared with subgroup analysis. Liver-to-lesion signal ratio (SR) was calculated using the region of interest method and compared.

RESULTS: Mean A(z) and sensitivities were significantly higher for 10- (A(z) = 0.894, sensitivity = 95.6%) and 20-minute (0.910, 97.2%) than dynamic set (0.813, 79.9%) (P < 0.001), with no significant difference between 10- and 20-minute sets (P = 0.140). In patients with small (≤1 cm) metastases and a history of chemotherapy, sensitivities were significantly higher with 10- (88.2%) and 20-minute (91.6%) sets than dynamic set (48.6%) (P < 0.001). SR was significantly higher for 10- and 20-minute delayed than precontrast and dynamic, with significantly higher SR on 20- than 10-minute delayed.

CONCLUSION: Regardless of size or prior chemotherapy, detection of hepatic metastases was significantly improved by adding hepatobiliary phase images without significant differences between 10- and 20-minute delayed.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jmri.22880/abstract
DOI
22095933
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Shin, Sang Joon(신상준) ORCID logo https://orcid.org/0000-0001-5350-7241
Choi, Gi Hong(최기홍) ORCID logo https://orcid.org/0000-0002-1593-3773
Choi, Jin Sub(최진섭)
Choi, Jin Young(최진영) ORCID logo https://orcid.org/0000-0002-9025-6274
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90947
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