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Gadoxetic acid-enhanced MRI findings of early hepatocellular carcinoma as defined by new histologic criteria

 Hyungjin Rhee  ;  Myeong-Jin Kim  ;  Young Nyun Park  ;  Jin-Sub Choi  ;  Kyung-Sik Kim 
 Journal of Magnetic Resonance Imaging, Vol.35(2) : 393-398, 2012 
Journal Title
 Journal of Magnetic Resonance Imaging 
Issue Date
Adult ; Aged ; Carcinoma, Hepatocellular/diagnosis* ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/pathology ; Contrast Media* ; Female ; Gadolinium DTPA* ; Humans ; Image Interpretation, Computer-Assisted ; Liver Neoplasms/diagnosis* ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Magnetic Resonance Imaging/methods* ; Male ; Middle Aged ; Retrospective Studies ; Tomography, X-Ray Computed
Gadolinium ethoxybenzyl diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA) ; liver magnetic reso-nance imaging (MRI) ; cirrhosis ; pathology ; diagnosis
PURPOSE: To describe the imaging features of early hepatocellular carcinoma (HCC) on gadoxetic acid-enhanced MRI (Gd-EOB-MRI) in comparison with multidetector computed tomography (MDCT) examinations. MATERIALS AND METHODS: We analyzed imaging findings of 19 pathologically proven early HCC lesions in 15 patients who underwent both MDCT and Gd-EOB-MRI at 3.0 Tesla (T) units before surgery. MRI included in-phase and out-of-phase T1-weighted dual-echo gradient-recalled-echo sequences, dynamic T1-weighted images before and after bolus injection of gadoxetic acid disodium, fat-saturated T2-weighted fast spin-echo sequences, and T1-weighted hepatobiliary phase images 20 min after contrast injection. Two radiologists retrospectively evaluated the signal intensities and enhancement features on MRI and MDCT. RESULTS: None of the lesions displayed arterial enhancement and washout on MDCT. On Gd-EOB-MRI, six (32%) lesions showed T2-hyperintensity, five (26%) lesions showed signal drop on opposed-phase. Three lesions (16%) showed arterial enhancement and washout. Twelve (63%), 13 (68%), and 15 (79%) lesions were hypointense on hepatic venous, equilibrium, and hepatobiliary phase, respectively. CONCLUSION: Most early HCCs did not show arterial enhancement and washout pattern on both MDCT and Gd-EOB-MRI. Gd-EOB-MRI may provide several ancillary findings for diagnosis of early HCC such as decreased hepatobiliary uptake, T2 hyperintensity and signal drop in opposed phase.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Rhee, Hyungjin(이형진) ORCID logo https://orcid.org/0000-0001-7759-4458
Choi, Jin Sub(최진섭)
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