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High incidence of rickets in extremely low birth weight infants with severe parenteral nutrition-associated cholestasis and bronchopulmonary dysplasiabronchopulmonary dysplasia

Authors
 Soon Min Lee  ;  Ran Namgung  ;  Min Soo Park  ;  Ho Sun Eun  ;  Kook In Park  ;  Chul Lee 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.27(12) : 1552-1555, 2012 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2012
MeSH
Alkaline Phosphatase/blood ; Birth Weight ; Bronchopulmonary Dysplasia/etiology* ; Case-Control Studies ; Cholestasis/etiology* ; Female ; Gestational Age ; Humans ; Incidence ; Infant ; Infant, Extremely Low Birth Weight ; Infant, Newborn ; Infant, Premature ; Male ; Parenteral Nutrition/adverse effects* ; Radiography ; Regression Analysis ; Retrospective Studies ; Rickets/diagnostic imaging ; Rickets/enzymology ; Rickets/epidemiology* ; Risk Factors ; Severity of Illness Index
Keywords
Bronchopulmonary Dysplasia ; Cholestasis ; Infant, Extremely Low Birth Weight ; Rickets ; Risk Factors
Abstract
Risk factors for rickets of prematurity have not been re-examined since introduction of high mineral formula, particularly in ELBW infants. We analyzed the incidence and the risk factors of rickets in extremely low birth weight (ELBW) infants. As a retrospective case-control study from 2004 to 2008, risk factors were analyzed in 24 patients with rickets versus 31 patients without. The frequency of rickets in ELBW infants was 24/55 (44%). Infants with rickets were diagnosed at 48.2 ± 16.1 days of age, and improved by 85.3 ± 25.3 days. By radiologic evaluation, 29% were grade 1 rickets, 58% grade 2 and 13% grade 3. In univariate analysis, infants with rickets had significantly higher incidence of patent ductus arteriosus, parenteral nutrition associated cholestasis (PNAC), severe PNAC and moderate/severe bronchopulmonary dysplasia (BPD). In multiple regression analysis, after adjustment for gestation and birth weight, rickets significantly correlated with severe PNAC and with moderate/severe BPD. Serum peak alkaline phosphatase levels were significantly elevated in rickets (P < 0.001). In ELBW infants, the incidence of rickets of prematurity remains high and the incidence of severe PNAC and moderate/severe BPD was significantly increased 18 and 3 times, respectively.
Files in This Item:
T201205200.pdf Download
DOI
23255857
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Namgung, Ran(남궁란) ORCID logo https://orcid.org/0000-0001-7182-9535
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
Park, Min Soo(박민수) ORCID logo https://orcid.org/0000-0002-4395-9938
Eun, Ho Seon(은호선) ORCID logo https://orcid.org/0000-0001-7212-0341
Lee, Soon Min(이순민) ORCID logo https://orcid.org/0000-0003-0174-1065
Lee, Chul(이철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90918
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