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Epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock: a prospective observational study in 12 university hospitals in Korea

Authors
 Dae Won Park  ;  Byung Chul Chun  ;  June Myung Kim  ;  Jang Wook Sohn  ;  Kyong Ran Peck  ;  Yang Soo Kim  ;  Young Hwa Choi  ;  Jun Yong Choi  ;  Sang Il Kim  ;  Joong Sik Eom  ;  Hyo Youl Kim  ;  Joon Young Song  ;  Young Goo Song  ;  Hee Jung Choi  ;  Min Ja Kim 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.27(11) : 1308-1314, 2012 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2012
MeSH
APACHE ; Adult ; Aged ; Aged, 80 and over ; Bacteremia/epidemiology ; Bacteremia/microbiology ; Community-Acquired Infections/epidemiology ; Community-Acquired Infections/microbiology ; Community-Acquired Infections/virology ; Comorbidity ; Female ; Hospital Mortality ; Hospitals, University ; Humans ; Intensive Care Units ; Logistic Models ; Lung Diseases/epidemiology ; Male ; Metabolic Diseases/epidemiology ; Middle Aged ; Neoplasms/epidemiology ; Odds Ratio ; Prospective Studies ; Republic of Korea ; Risk Factors ; Sepsis/diagnosis ; Sepsis/epidemiology* ; Sepsis/mortality ; Severity of Illness Index ; Sex Factors ; Shock, Septic/diagnosis ; Shock, Septic/epidemiology* ; Shock, Septic/mortality ; Urinary Tract Infections/epidemiology
Keywords
Epidemiology ; Gender ; Mortality ; Risk Factor ; Septic Shock ; Severe Sepsis
Abstract
A prospective multicenter observational study was performed to investigate the epidemiology and outcomes of community-acquired severe sepsis and septic shock. Subjects included 1,192 adult patients admitted to the 22 participating intensive care units (ICUs) of 12 university hospitals in the Korean Sepsis Registry System from April, 2005 through February, 2009. Male accounted for 656 (55%) patients. Mean age was 65.0 ± 14.2 yr. Septic shock developed in 740 (62.1%) patients. Bacteremia was present in 422 (35.4%) patients. The 28-day and in-hospital mortality rates were 23.0% and 28.0%, respectively. Men were more likely to have comorbid illnesses and acute organ dysfunctions, and had higher mortality and clinical severity compared to women. While respiratory sources of sepsis were common in men, urinary sources were predominant in women. In the multivariate logistic regression analysis, cancer (odds ratio 1.89; 95% confidence interval 1.13-3.17), urinary tract infection (0.25; 0.13-0.46), APACHE II score (1.05; 1.02-1.09), SOFA score on day 1 (1.13; 1.06-1.21) and metabolic dysfunction (2.24, 1.45-3.45) were independent clinical factors for gender-related in-hospital mortality. This study provided epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock in ICUs in Korea, and demonstrated the impact of clinical factors on gender difference in mortality.
Files in This Item:
T201205076.pdf Download
DOI
23166410
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, June Myung(김준명)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90917
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