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Epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock: a prospective observational study in 12 university hospitals in Korea

DC Field Value Language
dc.contributor.author송영구-
dc.contributor.author최준용-
dc.contributor.author김준명-
dc.date.accessioned2014-12-19T17:10:37Z-
dc.date.available2014-12-19T17:10:37Z-
dc.date.issued2012-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90917-
dc.description.abstractA prospective multicenter observational study was performed to investigate the epidemiology and outcomes of community-acquired severe sepsis and septic shock. Subjects included 1,192 adult patients admitted to the 22 participating intensive care units (ICUs) of 12 university hospitals in the Korean Sepsis Registry System from April, 2005 through February, 2009. Male accounted for 656 (55%) patients. Mean age was 65.0 ± 14.2 yr. Septic shock developed in 740 (62.1%) patients. Bacteremia was present in 422 (35.4%) patients. The 28-day and in-hospital mortality rates were 23.0% and 28.0%, respectively. Men were more likely to have comorbid illnesses and acute organ dysfunctions, and had higher mortality and clinical severity compared to women. While respiratory sources of sepsis were common in men, urinary sources were predominant in women. In the multivariate logistic regression analysis, cancer (odds ratio 1.89; 95% confidence interval 1.13-3.17), urinary tract infection (0.25; 0.13-0.46), APACHE II score (1.05; 1.02-1.09), SOFA score on day 1 (1.13; 1.06-1.21) and metabolic dysfunction (2.24, 1.45-3.45) were independent clinical factors for gender-related in-hospital mortality. This study provided epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock in ICUs in Korea, and demonstrated the impact of clinical factors on gender difference in mortality.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1308~1314-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAPACHE-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBacteremia/epidemiology-
dc.subject.MESHBacteremia/microbiology-
dc.subject.MESHCommunity-Acquired Infections/epidemiology-
dc.subject.MESHCommunity-Acquired Infections/microbiology-
dc.subject.MESHCommunity-Acquired Infections/virology-
dc.subject.MESHComorbidity-
dc.subject.MESHFemale-
dc.subject.MESHHospital Mortality-
dc.subject.MESHHospitals, University-
dc.subject.MESHHumans-
dc.subject.MESHIntensive Care Units-
dc.subject.MESHLogistic Models-
dc.subject.MESHLung Diseases/epidemiology-
dc.subject.MESHMale-
dc.subject.MESHMetabolic Diseases/epidemiology-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasms/epidemiology-
dc.subject.MESHOdds Ratio-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk Factors-
dc.subject.MESHSepsis/diagnosis-
dc.subject.MESHSepsis/epidemiology*-
dc.subject.MESHSepsis/mortality-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHSex Factors-
dc.subject.MESHShock, Septic/diagnosis-
dc.subject.MESHShock, Septic/epidemiology*-
dc.subject.MESHShock, Septic/mortality-
dc.subject.MESHUrinary Tract Infections/epidemiology-
dc.titleEpidemiological and clinical characteristics of community-acquired severe sepsis and septic shock: a prospective observational study in 12 university hospitals in Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorDae Won Park-
dc.contributor.googleauthorByung Chul Chun-
dc.contributor.googleauthorJune Myung Kim-
dc.contributor.googleauthorJang Wook Sohn-
dc.contributor.googleauthorKyong Ran Peck-
dc.contributor.googleauthorYang Soo Kim-
dc.contributor.googleauthorYoung Hwa Choi-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorSang Il Kim-
dc.contributor.googleauthorJoong Sik Eom-
dc.contributor.googleauthorHyo Youl Kim-
dc.contributor.googleauthorJoon Young Song-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorHee Jung Choi-
dc.contributor.googleauthorMin Ja Kim-
dc.identifier.doi23166410-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02037-
dc.contributor.localIdA04191-
dc.contributor.localIdA00953-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid23166410-
dc.subject.keywordEpidemiology-
dc.subject.keywordGender-
dc.subject.keywordMortality-
dc.subject.keywordRisk Factor-
dc.subject.keywordSeptic Shock-
dc.subject.keywordSevere Sepsis-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.affiliatedAuthorSong, Young Goo-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.citation.volume27-
dc.citation.number11-
dc.citation.startPage1308-
dc.citation.endPage1314-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.27(11) : 1308-1314, 2012-
dc.identifier.rimsid33212-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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