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Low-grade inflammation, metabolic syndrome and the risk of chronic kidney disease: the 2005 Korean National Health and Nutrition Examination Survey

Authors
 Hee-Taik Kang  ;  Jong-Koo Kim  ;  Jae-Yong Shim  ;  Hye-Ree Lee  ;  John A. Linton  ;  Yong-Jae Lee 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.27(6) : 630-635, 2012 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2012
MeSH
Adult ; Cross-Sectional Studies ; Female ; Glomerular Filtration Rate ; Humans ; Inflammation/complications ; Inflammation/diagnosis* ; Kidney Failure, Chronic/epidemiology* ; Kidney Failure, Chronic/etiology ; Leukocyte Count ; Male ; Metabolic Syndrome/complications ; Metabolic Syndrome/diagnosis* ; Middle Aged ; Nutrition Surveys ; Odds Ratio ; Prevalence ; Republic of Korea/epidemiology ; Risk Factors ; Severity of Illness Index
Keywords
Inflammation ; Kidney Failure, Chronic ; Leukocytes ; Metabolic Syndrome
Abstract
Either chronic inflammation or metabolic syndrome (MetS) is associated with renal impairment. This cross-sectional study was designed to investigate the relationship between elevated white blood cell (WBC) counts and chronic kidney disease (CKD) stage 3 or more according to the presence of MetS in adult Koreans. In total, 5,291 subjects (≥ 20 yr-old) participating in the 2005 Korean National Health and Nutrition Examination were included. CKD stage 3 or more was defined as having an estimated glomerular filtration rate below 60 mL/min/1.73 m(2), as calculated using the formula from the Modification of Diet in Renal Disease study. The odds ratio (95% confidence interval) for CKD stage 3 or more in the highest WBC quartile (≥ 7,200 cells/µL) was 1.70 (1.17-2.39) after adjusting for MetS and other covariates, compared with the lowest WBC quartile (< 5,100 cells/µL). In subjects with MetS, the prevalence risk for CKD stage 3 or more in the highest WBC quartile was 2.25 (1.28-3.95) even after fully adjusting for confounding variables. In contrast, this positive association between WBC quartile and CKD stage 3 or more disappeared in subjects without MetS. Low-grade inflammation is significantly associated with CKD stage 3 or more in subjects with MetS but not in those without MetS.
Files in This Item:
T201202377.pdf Download
DOI
22690094
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hee Taik(강희택)
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Hye Ree(이혜리)
Linton, John A.(인요한) ORCID logo https://orcid.org/0000-0001-8000-3049
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90895
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