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Questionable role of interferon-γ assays for smear-negative pulmonary TB in immunocompromised patients

DC FieldValueLanguage
dc.contributor.author장준-
dc.contributor.author정지예-
dc.contributor.author조상래-
dc.contributor.author강영애-
dc.contributor.author김세규-
dc.contributor.author이혜정-
dc.contributor.author임주은-
dc.date.accessioned2014-12-19T17:08:26Z-
dc.date.available2014-12-19T17:08:26Z-
dc.date.issued2012-
dc.identifier.issn0163-4453-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90852-
dc.description.abstractOBJECTIVE: The purpose of this study was to examine the usefulness of the TST and the interferon-γ release assays (IGRA) for diagnosing smear-negative pulmonary TB in immunocompromised patients in an intermediate TB burden. METHODS: We conducted a prospective study enrolling 119 immunocompromised participants with suspected smear-negative pulmonary TB in Seoul, South Korea. Clinical assessment, TST, QuantiFERON-TB Gold In Tube (QFT-GIT), and T-SPOT.TB were performed in immunosuppressed condition. RESULTS: All participants were categorized according to the type of immunosuppression: 29 patients with diabetes mellitus, 53 with malignancy, 23 with taking immunosuppressive drugs, and 14 with end stage renal disease. IGRA sensitivity and specificity (95% CI) were: QFT-GIT [59.0% (44.9-72.0)] and [61.3% (54.4-67.6)] and T-SPOT.TB [72.0% (54.2-86.2)] and [42.3% (33.8-49.1)], respectively. For TST, sensitivity was 41.2% (28.3-50.8) and specificity was 91.8% (85.8-96.30). The sensitivities of the three diagnostic methods tended to be lower in the immunosuppressive drug group than in other groups (QFT-GIT 11.1%, T-SPOT.TB 40.0% and TST 25.0% in patients with taking immunosuppressive drugs). Among 111 patients who underwent a chest CT examination, there were no significant differences in the CT findings between the immunocompromised TB and non-TB patients. CONCLUSIONS: The IGRAs and TST had no value as a single test either to rule-in or rule-out active TB in immunocompromised patients in an intermediate burden.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF INFECTION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunocompromised Host*-
dc.subject.MESHInterferon-gamma/analysis-
dc.subject.MESHInterferon-gamma Release Tests/methods*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHReagent Kits, Diagnostic-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHTuberculin Test/methods*-
dc.subject.MESHTuberculosis, Pulmonary/diagnosis*-
dc.subject.MESHTuberculosis, Pulmonary/immunology-
dc.titleQuestionable role of interferon-γ assays for smear-negative pulmonary TB in immunocompromised patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJi Ye Jung-
dc.contributor.googleauthorJu Eun Lim-
dc.contributor.googleauthorHye-jeong Lee-
dc.contributor.googleauthorYoung Mi Kim-
dc.contributor.googleauthorSang-Nae Cho-
dc.contributor.googleauthorSe Kyu Kim-
dc.contributor.googleauthorJoon Chang-
dc.contributor.googleauthorYoung Ae Kang-
dc.identifier.doi22120597-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03472-
dc.contributor.localIdA03735-
dc.contributor.localIdA03824-
dc.contributor.localIdA00057-
dc.contributor.localIdA00602-
dc.contributor.localIdA03407-
dc.contributor.localIdA03320-
dc.relation.journalcodeJ01452-
dc.identifier.eissn1532-2742-
dc.identifier.pmid22120597-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0163445311005597-
dc.subject.keywordDiagnostics-
dc.subject.keywordTuberculosis-
dc.subject.keywordInterferon-γ release assays-
dc.subject.keywordImmunocompromised-
dc.contributor.alternativeNameChang, Joon-
dc.contributor.alternativeNameJung, Ji Ye-
dc.contributor.alternativeNameCho, Sang Nae-
dc.contributor.alternativeNameKang, Young Ae-
dc.contributor.alternativeNameKim, Se Kyu-
dc.contributor.alternativeNameLee, Hye Jeong-
dc.contributor.alternativeNameLim, Ju Eun-
dc.contributor.affiliatedAuthorChang, Joon-
dc.contributor.affiliatedAuthorJung, Ji Ye-
dc.contributor.affiliatedAuthorCho, Sang Nae-
dc.contributor.affiliatedAuthorKang, Young Ae-
dc.contributor.affiliatedAuthorKim, Se Kyu-
dc.contributor.affiliatedAuthorLim, Ju Eun-
dc.contributor.affiliatedAuthorLee, Hye Jeong-
dc.citation.volume64-
dc.citation.number2-
dc.citation.startPage188-
dc.citation.endPage196-
dc.identifier.bibliographicCitationJOURNAL OF INFECTION, Vol.64(2) : 188-196, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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