Cited 31 times in
Questionable role of interferon-γ assays for smear-negative pulmonary TB in immunocompromised patients
DC Field | Value | Language |
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dc.contributor.author | 장준 | - |
dc.contributor.author | 정지예 | - |
dc.contributor.author | 조상래 | - |
dc.contributor.author | 강영애 | - |
dc.contributor.author | 김세규 | - |
dc.contributor.author | 이혜정 | - |
dc.contributor.author | 임주은 | - |
dc.date.accessioned | 2014-12-19T17:08:26Z | - |
dc.date.available | 2014-12-19T17:08:26Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0163-4453 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90852 | - |
dc.description.abstract | OBJECTIVE: The purpose of this study was to examine the usefulness of the TST and the interferon-γ release assays (IGRA) for diagnosing smear-negative pulmonary TB in immunocompromised patients in an intermediate TB burden. METHODS: We conducted a prospective study enrolling 119 immunocompromised participants with suspected smear-negative pulmonary TB in Seoul, South Korea. Clinical assessment, TST, QuantiFERON-TB Gold In Tube (QFT-GIT), and T-SPOT.TB were performed in immunosuppressed condition. RESULTS: All participants were categorized according to the type of immunosuppression: 29 patients with diabetes mellitus, 53 with malignancy, 23 with taking immunosuppressive drugs, and 14 with end stage renal disease. IGRA sensitivity and specificity (95% CI) were: QFT-GIT [59.0% (44.9-72.0)] and [61.3% (54.4-67.6)] and T-SPOT.TB [72.0% (54.2-86.2)] and [42.3% (33.8-49.1)], respectively. For TST, sensitivity was 41.2% (28.3-50.8) and specificity was 91.8% (85.8-96.30). The sensitivities of the three diagnostic methods tended to be lower in the immunosuppressive drug group than in other groups (QFT-GIT 11.1%, T-SPOT.TB 40.0% and TST 25.0% in patients with taking immunosuppressive drugs). Among 111 patients who underwent a chest CT examination, there were no significant differences in the CT findings between the immunocompromised TB and non-TB patients. CONCLUSIONS: The IGRAs and TST had no value as a single test either to rule-in or rule-out active TB in immunocompromised patients in an intermediate burden. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF INFECTION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunocompromised Host* | - |
dc.subject.MESH | Interferon-gamma/analysis | - |
dc.subject.MESH | Interferon-gamma Release Tests/methods* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Reagent Kits, Diagnostic | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Tuberculin Test/methods* | - |
dc.subject.MESH | Tuberculosis, Pulmonary/diagnosis* | - |
dc.subject.MESH | Tuberculosis, Pulmonary/immunology | - |
dc.title | Questionable role of interferon-γ assays for smear-negative pulmonary TB in immunocompromised patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ji Ye Jung | - |
dc.contributor.googleauthor | Ju Eun Lim | - |
dc.contributor.googleauthor | Hye-jeong Lee | - |
dc.contributor.googleauthor | Young Mi Kim | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.contributor.googleauthor | Se Kyu Kim | - |
dc.contributor.googleauthor | Joon Chang | - |
dc.contributor.googleauthor | Young Ae Kang | - |
dc.identifier.doi | 10.1016/j.jinf.2011.09.008 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03472 | - |
dc.contributor.localId | A03735 | - |
dc.contributor.localId | A03824 | - |
dc.contributor.localId | A00057 | - |
dc.contributor.localId | A00602 | - |
dc.contributor.localId | A03407 | - |
dc.contributor.localId | A03320 | - |
dc.relation.journalcode | J01452 | - |
dc.identifier.eissn | 1532-2742 | - |
dc.identifier.pmid | 22120597 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0163445311005597 | - |
dc.subject.keyword | Diagnostics | - |
dc.subject.keyword | Tuberculosis | - |
dc.subject.keyword | Interferon-γ release assays | - |
dc.subject.keyword | Immunocompromised | - |
dc.contributor.alternativeName | Chang, Joon | - |
dc.contributor.alternativeName | Jung, Ji Ye | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.alternativeName | Kang, Young Ae | - |
dc.contributor.alternativeName | Kim, Se Kyu | - |
dc.contributor.alternativeName | Lee, Hye Jeong | - |
dc.contributor.alternativeName | Lim, Ju Eun | - |
dc.contributor.affiliatedAuthor | Chang, Joon | - |
dc.contributor.affiliatedAuthor | Jung, Ji Ye | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Kang, Young Ae | - |
dc.contributor.affiliatedAuthor | Kim, Se Kyu | - |
dc.contributor.affiliatedAuthor | Lim, Ju Eun | - |
dc.contributor.affiliatedAuthor | Lee, Hye Jeong | - |
dc.citation.volume | 64 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 188 | - |
dc.citation.endPage | 196 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INFECTION, Vol.64(2) : 188-196, 2012 | - |
dc.identifier.rimsid | 34565 | - |
dc.type.rims | ART | - |
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