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"Normal" liver stiffness values differ between men and women: a prospective study for healthy living liver and kidney donors in a native Korean population

Authors
 Beom Kyung Kim  ;  Seung Up Kim  ;  Gi Hong Choi  ;  Woong Kyu Han  ;  Mi Sung Park  ;  Eun Hye Kim  ;  Jun Yong Park  ;  Do Young Kim  ;  Jin Sub Choi  ;  Seung Choul Yang  ;  Eun Hee Choi  ;  Kijun Song  ;  Sang Hoon Ahn  ;  Kwang-Hyub Han  ;  Chae Yoon Chon 
Citation
 JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.27(4) : 781-788, 2012 
Journal Title
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
ISSN
 0815-9319 
Issue Date
2012
MeSH
Adult ; Alanine Transaminase/blood ; Alkaline Phosphatase/blood ; Aspartate Aminotransferases/blood ; Elasticity/physiology* ; Female ; Humans ; Kidney Transplantation ; Linear Models ; Liver/physiology* ; Liver Transplantation ; Male ; Middle Aged ; Multivariate Analysis ; Prospective Studies ; Reference Values ; Republic of Korea ; Sex Factors ; Young Adult
Keywords
healthy individual ; liver stiffness measurement ; sex ; transplantation
Abstract
BACKGROUND AND AIM: Liver stiffness (LS) measurement can distinguish individuals with potential liver disease (LD) from the general population. However, if LS is sex-sensitive, prevalence of LD may be incorrectly estimated when the same reference LS value is applied irrespective of sex. Here, we evaluated whether normal ranges of LS differ between healthy men and women.

METHODS: LS was measured in a cohort of healthy living liver and kidney donors, none of whom suffered from diabetes mellitus, hypertension, hepatitis B or C virus infection, heart or liver dysfunction, or metabolic syndrome. Patients with abnormal laboratory findings related to potential LD (platelet count < 150 × 10(3) /µL; aspartate aminotransferase > 40 IU/L; alanine aminotransferase [ALT] > 40 IU/L; albumin < 3.3 g/dL; total bilirubin > 1.2 mg/dL; gamma-glutamyl transpeptidase > 54 IU/L; alkaline phosphatase > 115 IU/L) were excluded.

RESULTS: Among 242 patients analyzed, the mean age was 34.1 for men (n = 121) and 40.5 years for women (n = 121) (P < 0.001). Men had a higher mean LS value than women (5.2 ± 1.2 vs 4.8 ± 1.1 kPa/P < 0.001). Multivariate-linear regression analysis identified sex as the only independent factor for LS values (β = 0.361/P = 0.021). Using the 5th-95th percentiles, we determined normal LS ranges of 3.7-7.0 kPa in men and 3.3-6.8 kPa in women. In subgroups with ALT < 30 IU/L (subgroup-1, n = 216) and ALT < 20 IU/L (subgroup-2, n = 163), men had significantly higher LS values than women (5.2 ± 1.3 vs 4.7 ± 1.1 kPa/P = 0.003 and 5.1 ± 1.2 vs 4.7 ± 1.1 kPa/P = 0.030, respectively), demonstrating an independent sex effect (β = 0.483/P = 0.003 and β = 0.389/P = 0.030, respectively).

CONCLUSIONS: An independent sex effect on LS values was confirmed. Thus, sex-specific references should be used for effective screening based on LS measurements.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2011.06962.x/abstract
DOI
22098121
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Kim, Eun Hye(김은혜) ORCID logo https://orcid.org/0000-0001-6691-6837
Park, Mi Sung(박미성)
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Song, Ki Jun(송기준) ORCID logo https://orcid.org/0000-0003-2505-4112
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Yang, Seung Choul(양승철)
Chon, Chae Yoon(전재윤)
Choi, Gi Hong(최기홍) ORCID logo https://orcid.org/0000-0002-1593-3773
Choi, Eun Hee(최은희)
Choi, Jin Sub(최진섭)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90812
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