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"Normal" liver stiffness values differ between men and women: a prospective study for healthy living liver and kidney donors in a native Korean population

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dc.contributor.author박준용-
dc.contributor.author한웅규-
dc.contributor.author송기준-
dc.contributor.author안상훈-
dc.contributor.author양승철-
dc.contributor.author김도영-
dc.contributor.author전재윤-
dc.contributor.author김범경-
dc.contributor.author최기홍-
dc.contributor.author김승업-
dc.contributor.author최은희-
dc.contributor.author김은혜-
dc.contributor.author최진섭-
dc.contributor.author박미성-
dc.contributor.author한광협-
dc.date.accessioned2014-12-19T17:07:09Z-
dc.date.available2014-12-19T17:07:09Z-
dc.date.issued2012-
dc.identifier.issn0815-9319-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90812-
dc.description.abstractBACKGROUND AND AIM: Liver stiffness (LS) measurement can distinguish individuals with potential liver disease (LD) from the general population. However, if LS is sex-sensitive, prevalence of LD may be incorrectly estimated when the same reference LS value is applied irrespective of sex. Here, we evaluated whether normal ranges of LS differ between healthy men and women. METHODS: LS was measured in a cohort of healthy living liver and kidney donors, none of whom suffered from diabetes mellitus, hypertension, hepatitis B or C virus infection, heart or liver dysfunction, or metabolic syndrome. Patients with abnormal laboratory findings related to potential LD (platelet count < 150 × 10(3) /µL; aspartate aminotransferase > 40 IU/L; alanine aminotransferase [ALT] > 40 IU/L; albumin < 3.3 g/dL; total bilirubin > 1.2 mg/dL; gamma-glutamyl transpeptidase > 54 IU/L; alkaline phosphatase > 115 IU/L) were excluded. RESULTS: Among 242 patients analyzed, the mean age was 34.1 for men (n = 121) and 40.5 years for women (n = 121) (P < 0.001). Men had a higher mean LS value than women (5.2 ± 1.2 vs 4.8 ± 1.1 kPa/P < 0.001). Multivariate-linear regression analysis identified sex as the only independent factor for LS values (β = 0.361/P = 0.021). Using the 5th-95th percentiles, we determined normal LS ranges of 3.7-7.0 kPa in men and 3.3-6.8 kPa in women. In subgroups with ALT < 30 IU/L (subgroup-1, n = 216) and ALT < 20 IU/L (subgroup-2, n = 163), men had significantly higher LS values than women (5.2 ± 1.3 vs 4.7 ± 1.1 kPa/P = 0.003 and 5.1 ± 1.2 vs 4.7 ± 1.1 kPa/P = 0.030, respectively), demonstrating an independent sex effect (β = 0.483/P = 0.003 and β = 0.389/P = 0.030, respectively). CONCLUSIONS: An independent sex effect on LS values was confirmed. Thus, sex-specific references should be used for effective screening based on LS measurements.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAlanine Transaminase/blood-
dc.subject.MESHAlkaline Phosphatase/blood-
dc.subject.MESHAspartate Aminotransferases/blood-
dc.subject.MESHElasticity/physiology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKidney Transplantation-
dc.subject.MESHLinear Models-
dc.subject.MESHLiver/physiology*-
dc.subject.MESHLiver Transplantation-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHProspective Studies-
dc.subject.MESHReference Values-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSex Factors-
dc.subject.MESHYoung Adult-
dc.title"Normal" liver stiffness values differ between men and women: a prospective study for healthy living liver and kidney donors in a native Korean population-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorBeom Kyung Kim-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorGi Hong Choi-
dc.contributor.googleauthorWoong Kyu Han-
dc.contributor.googleauthorMi Sung Park-
dc.contributor.googleauthorEun Hye Kim-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorJin Sub Choi-
dc.contributor.googleauthorSeung Choul Yang-
dc.contributor.googleauthorEun Hee Choi-
dc.contributor.googleauthorKijun Song-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorChae Yoon Chon-
dc.identifier.doi22098121-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01675-
dc.contributor.localIdA04308-
dc.contributor.localIdA02016-
dc.contributor.localIdA02226-
dc.contributor.localIdA02294-
dc.contributor.localIdA00487-
dc.contributor.localIdA04046-
dc.contributor.localIdA00654-
dc.contributor.localIdA04163-
dc.contributor.localIdA04199-
dc.contributor.localIdA01462-
dc.contributor.localIdA04268-
dc.contributor.localIdA03544-
dc.contributor.localIdA00827-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ01417-
dc.identifier.eissn1440-1746-
dc.identifier.pmid22098121-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2011.06962.x/abstract-
dc.subject.keywordhealthy individual-
dc.subject.keywordliver stiffness measurement-
dc.subject.keywordsex-
dc.subject.keywordtransplantation-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameHan, Woong Kyu-
dc.contributor.alternativeNameSong, Ki Jun-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameYang, Seung Choul-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameChon, Chae Yoon-
dc.contributor.alternativeNameKim, Beom Kyung-
dc.contributor.alternativeNameChoi, Gi Hong-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNameChoi, Eun Hee-
dc.contributor.alternativeNameKim, Eun Hye-
dc.contributor.alternativeNameChoi, Jin Sub-
dc.contributor.alternativeNamePark, Mi Sung-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorHan, Woong Kyu-
dc.contributor.affiliatedAuthorSong, Ki Jun-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorYang, Seung Choul-
dc.contributor.affiliatedAuthorKim, Beom Kyung-
dc.contributor.affiliatedAuthorChoi, Gi Hong-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorChoi, Eun Hee-
dc.contributor.affiliatedAuthorChoi, Jin Sub-
dc.contributor.affiliatedAuthorPark, Mi Sung-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorChon, Chae Yoon-
dc.contributor.affiliatedAuthorKim, Eun Hye-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.citation.volume27-
dc.citation.number4-
dc.citation.startPage781-
dc.citation.endPage788-
dc.identifier.bibliographicCitationJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.27(4) : 781-788, 2012-
dc.identifier.rimsid33549-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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