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Viral shedding of 2009 pandemic H1N1 and evaluation of quarantine recommendations

Authors
 Bum Sik Chin  ;  Yun Tae Chae  ;  Hee Kyung Choi  ;  Ji-Hyeon Baek  ;  Sung Joon Jin  ;  So Youn Shin  ;  Sang Hoon Han  ;  Jun Yong Choi  ;  Chan Oh Kim  ;  Young Goo Song  ;  Seok Hoon Jeong  ;  June Myung Kim 
Citation
 JAPANESE JOURNAL OF INFECTIOUS DISEASES, Vol.65(2) : 105-110, 2012 
Journal Title
 JAPANESE JOURNAL OF INFECTIOUS DISEASES 
ISSN
 1344-6304 
Issue Date
2012
MeSH
Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Influenza A Virus, H1N1 Subtype/isolation & purification* ; Influenza, Human/pathology ; Influenza, Human/virology* ; Longitudinal Studies ; Male ; Middle Aged ; Oropharynx/virology ; Quarantine/methods* ; Real-Time Polymerase Chain Reaction ; Time Factors ; Viral Load ; Virus Shedding*
Keywords
Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Influenza A Virus, H1N1 Subtype/isolation & purification* ; Influenza, Human/pathology ; Influenza, Human/virology* ; Longitudinal Studies ; Male ; Middle Aged ; Oropharynx/virology ; Quarantine/methods* ; Real-Time Polymerase Chain Reaction ; Time Factors ; Viral Load ; Virus Shedding*
Abstract
Public health authorities recommend that isolation precautions for influenza should be continued for 7 days after illness onset or until 24 h after the resolution of symptoms, whichever event lasts longer. However, little data are available regarding the duration of isolation for patients with 2009 pandemic H1N1 (pH1N1). We recruited patients with confirmed pH1N1 virus infection at a 2,000-bed tertiary care center. Influenza viral loads from oropharyngeal swab specimens were serially determined by reverse transcriptase quantitative polymerase chain reaction every other day, and the risk factors for prolonged viral shedding were investigated. To evaluate the current recommendations for isolation precautions, we measured the intervals between symptom onset and the last viral RNA detection, and that between the last viral RNA detection and the point at which the patient was symptom-free for 24 h. From November 2009 to January 2010, 26 patients were enrolled, and viral RNA was detected in more than half of the eligible patients (10 of 19, 52.6%) for ≥7 days after symptom onset. While evaluating the policy for lifting quarantine, we found that viral RNA was detected in 4 of 15 patients (26.7%) beyond the recommended duration of isolation. In conclusion, viral RNA was detected in a substantial proportion of hospitalized patients even when they fulfilled the recommended conditions for lifting quarantine, and we believe that more prudence is required in this aspect.
Files in This Item:
T201200688.pdf Download
DOI
22446115
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, June Myung(김준명)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Baek, Ji Hyeon(백지현)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Shin, So Youn(신소연)
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
Chin, Bum Sik(진범식)
Jin, Sung Joon(진성준)
Chae, Yun Tae(채윤태)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
Choi, Hee Kyoung(최희경)
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90596
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