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Viral shedding of 2009 pandemic H1N1 and evaluation of quarantine recommendations

 Bum Sik Chin  ;  Yun Tae Chae  ;  Hee Kyung Choi  ;  Ji-Hyeon Baek  ;  Sung Joon Jin  ;  So Youn Shin  ;  Sang Hoon Han  ;  Jun Yong Choi  ;  Chan Oh Kim  ;  Young Goo Song  ;  Seok Hoon Jeong  ;  June Myung Kim 
 Japanese Journal of Infectious Diseases, Vol.65(2) : 105-110, 2012 
Journal Title
 Japanese Journal of Infectious Diseases 
Issue Date
Public health authorities recommend that isolation precautions for influenza should be continued for 7 days after illness onset or until 24 h after the resolution of symptoms, whichever event lasts longer. However, little data are available regarding the duration of isolation for patients with 2009 pandemic H1N1 (pH1N1). We recruited patients with confirmed pH1N1 virus infection at a 2,000-bed tertiary care center. Influenza viral loads from oropharyngeal swab specimens were serially determined by reverse transcriptase quantitative polymerase chain reaction every other day, and the risk factors for prolonged viral shedding were investigated. To evaluate the current recommendations for isolation precautions, we measured the intervals between symptom onset and the last viral RNA detection, and that between the last viral RNA detection and the point at which the patient was symptom-free for 24 h. From November 2009 to January 2010, 26 patients were enrolled, and viral RNA was detected in more than half of the eligible patients (10 of 19, 52.6%) for ≥7 days after symptom onset. While evaluating the policy for lifting quarantine, we found that viral RNA was detected in 4 of 15 patients (26.7%) beyond the recommended duration of isolation. In conclusion, viral RNA was detected in a substantial proportion of hospitalized patients even when they fulfilled the recommended conditions for lifting quarantine, and we believe that more prudence is required in this aspect.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김준명(Kim, June Myung)
김창오(Kim, Chang Oh) ORCID logo https://orcid.org/0000-0002-0773-5443
백지현(Baek, Ji Hyeon)
송영구(Song, Young Goo) ORCID logo https://orcid.org/0000-0002-0733-4156
신소연(Shin, So Youn)
정석훈(Jeong, Seok Hoon) ORCID logo https://orcid.org/0000-0001-9290-897X
진범식(Chin, Bum Sik)
진성준(Jin, Sung Joon)
채윤태(Chae, Yun Tae)
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
최희경(Choi, Hee Kyoung)
한상훈(Han, Sang Hoon) ORCID logo https://orcid.org/0000-0002-4278-5198
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