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Combination of preS deletions and A1762T/G1764A mutations in HBV subgenotype C2 increases the risk of developing HCC.

 Myoung Ha Lee  ;  Do Young Kim  ;  Ja Kyung Kim  ;  Hye Young Chang  ;  Se Hun Kang  ;  Han Jak Ryu  ;  Hye-Lim Ju  ;  Seung Up Kim  ;  Jung Min Lee  ;  Jun Yong Park  ;  Kwang-Hyub Han  ;  Chae Yoon Chon  ;  Sang Hoon Ahn 
 INTERVIROLOGY, Vol.55(4) : 296-302, 2012 
Journal Title
Issue Date
Adult ; Carcinoma, Hepatocellular/epidemiology ; Carcinoma, Hepatocellular/virology* ; Female ; Genotype ; Hepatitis B Surface Antigens/genetics* ; Hepatitis B virus/genetics* ; Hepatitis B virus/isolation & purification ; Hepatitis B virus/pathogenicity* ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/virology* ; Humans ; Male ; Middle Aged ; Molecular Sequence Data ; Mutation ; Protein Precursors/genetics* ; Republic of Korea ; Risk Assessment ; Sequence Analysis, DNA ; Sequence Deletion ; Virulence Factors/genetics*
Hepatitis B virus ; Hepatocellular carcinoma ; preS deletions ; A1762T/G1764A mutations ; G1896A mutation
BACKGROUND: The interactions among hepatitis B virus (HBV) mutations in developing hepatocellular carcinoma (HCC) remain unclear and thus we investigated the risk of HCC related with single or multiple HBV mutations in Korean patients infected with HBV subgenotype C2.

METHODS: From January 2003 to December 2008, HBV isolates from 135 patients with HCC were compared with those from 135 patients without HCC, matching for age, gender, and HBeAg status. The prevalence of preS deletions and G1896A and A1762T/G1764A mutations was evaluated.

RESULTS: The frequency of preS deletions significantly differed between the non-HCC and HCC groups, with 6 (4.4%) versus 25 (18.5%) patients, respectively (p < 0.001). Additionally, the frequency of A1762T/G1764A mutations was higher in the HCC than the non-HCC group [82 (60.7%) versus 30 (22.2%), p < 0.001]. For combined mutations, the odds ratio (OR) was highest in patients with both preS deletions and the A1762T/G1764A mutation, with 1 (0.7%) versus 11 (8.1%) patients (p = 0.005; OR 11.887).

CONCLUSIONS: HCC was associated with preS deletions and A1762T/G1764A mutations, and the combination of both mutations had a stronger association with HCC in Korean patients infected with HBV subgenotype C2.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kang, Se Hun(강세훈)
Kim, Do Young(김도영)
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Kim, Ja Kyung(김자경) ORCID logo https://orcid.org/0000-0001-5025-6846
Ryu, Han Jak(류한작)
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Myoung Ha(이명하)
Lee, Jung Min(이중민)
Chon, Chae Yoon(전재윤)
Ju, Hye Lim(주혜림)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
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