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Combination of preS deletions and A1762T/G1764A mutations in HBV subgenotype C2 increases the risk of developing HCC.
DC Field | Value | Language |
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dc.contributor.author | 김도영 | - |
dc.contributor.author | 김승업 | - |
dc.contributor.author | 김자경 | - |
dc.contributor.author | 류한작 | - |
dc.contributor.author | 박준용 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 이명하 | - |
dc.contributor.author | 이중민 | - |
dc.contributor.author | 전재윤 | - |
dc.contributor.author | 주혜림 | - |
dc.contributor.author | 한광협 | - |
dc.contributor.author | 강세훈 | - |
dc.date.accessioned | 2014-12-19T16:59:06Z | - |
dc.date.available | 2014-12-19T16:59:06Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0300-5526 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90563 | - |
dc.description.abstract | BACKGROUND: The interactions among hepatitis B virus (HBV) mutations in developing hepatocellular carcinoma (HCC) remain unclear and thus we investigated the risk of HCC related with single or multiple HBV mutations in Korean patients infected with HBV subgenotype C2. METHODS: From January 2003 to December 2008, HBV isolates from 135 patients with HCC were compared with those from 135 patients without HCC, matching for age, gender, and HBeAg status. The prevalence of preS deletions and G1896A and A1762T/G1764A mutations was evaluated. RESULTS: The frequency of preS deletions significantly differed between the non-HCC and HCC groups, with 6 (4.4%) versus 25 (18.5%) patients, respectively (p < 0.001). Additionally, the frequency of A1762T/G1764A mutations was higher in the HCC than the non-HCC group [82 (60.7%) versus 30 (22.2%), p < 0.001]. For combined mutations, the odds ratio (OR) was highest in patients with both preS deletions and the A1762T/G1764A mutation, with 1 (0.7%) versus 11 (8.1%) patients (p = 0.005; OR 11.887). CONCLUSIONS: HCC was associated with preS deletions and A1762T/G1764A mutations, and the combination of both mutations had a stronger association with HCC in Korean patients infected with HBV subgenotype C2. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | INTERVIROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Carcinoma, Hepatocellular/epidemiology | - |
dc.subject.MESH | Carcinoma, Hepatocellular/virology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Hepatitis B Surface Antigens/genetics* | - |
dc.subject.MESH | Hepatitis B virus/genetics* | - |
dc.subject.MESH | Hepatitis B virus/isolation & purification | - |
dc.subject.MESH | Hepatitis B virus/pathogenicity* | - |
dc.subject.MESH | Hepatitis C, Chronic/complications | - |
dc.subject.MESH | Hepatitis C, Chronic/virology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Protein Precursors/genetics* | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Sequence Analysis, DNA | - |
dc.subject.MESH | Sequence Deletion | - |
dc.subject.MESH | Virulence Factors/genetics* | - |
dc.title | Combination of preS deletions and A1762T/G1764A mutations in HBV subgenotype C2 increases the risk of developing HCC. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Myoung Ha Lee | - |
dc.contributor.googleauthor | Do Young Kim | - |
dc.contributor.googleauthor | Ja Kyung Kim | - |
dc.contributor.googleauthor | Hye Young Chang | - |
dc.contributor.googleauthor | Se Hun Kang | - |
dc.contributor.googleauthor | Han Jak Ryu | - |
dc.contributor.googleauthor | Hye-Lim Ju | - |
dc.contributor.googleauthor | Seung Up Kim | - |
dc.contributor.googleauthor | Jung Min Lee | - |
dc.contributor.googleauthor | Jun Yong Park | - |
dc.contributor.googleauthor | Kwang-Hyub Han | - |
dc.contributor.googleauthor | Chae Yoon Chon | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.identifier.doi | 21865669 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00654 | - |
dc.contributor.localId | A00852 | - |
dc.contributor.localId | A01334 | - |
dc.contributor.localId | A01675 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A02758 | - |
dc.contributor.localId | A03961 | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A00043 | - |
dc.contributor.localId | A03184 | - |
dc.contributor.localId | A03544 | - |
dc.contributor.localId | A00385 | - |
dc.relation.journalcode | J01181 | - |
dc.identifier.eissn | 1423-0100 | - |
dc.identifier.pmid | 21865669 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/329941 | - |
dc.subject.keyword | Hepatitis B virus | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | preS deletions | - |
dc.subject.keyword | A1762T/G1764A mutations | - |
dc.subject.keyword | G1896A mutation | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.alternativeName | Kim, Seung Up | - |
dc.contributor.alternativeName | Kim, Ja Kyung | - |
dc.contributor.alternativeName | Ryu, Han Jak | - |
dc.contributor.alternativeName | Park, Jun Yong | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | Lee, Myoung Ha | - |
dc.contributor.alternativeName | Lee, Jung Min | - |
dc.contributor.alternativeName | Chon, Chae Yoon | - |
dc.contributor.alternativeName | Ju, Hye Lim | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.alternativeName | Kang, Se Hun | - |
dc.contributor.affiliatedAuthor | Kim, Seung Up | - |
dc.contributor.affiliatedAuthor | Kim, Ja Kyung | - |
dc.contributor.affiliatedAuthor | Ryu, Han Jak | - |
dc.contributor.affiliatedAuthor | Park, Jun Yong | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Myoung Ha | - |
dc.contributor.affiliatedAuthor | Ju, Hye Lim | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kang, Se Hun | - |
dc.contributor.affiliatedAuthor | Lee, Jung Min | - |
dc.contributor.affiliatedAuthor | Chon, Chae Yoon | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.citation.volume | 55 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 296 | - |
dc.citation.endPage | 302 | - |
dc.identifier.bibliographicCitation | INTERVIROLOGY, Vol.55(4) : 296-302, 2012 | - |
dc.identifier.rimsid | 32835 | - |
dc.type.rims | ART | - |
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