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Alpha amplitude and phase locking in obsessive-compulsive disorder during working memory

Authors
 Jin Young Park  ;  Jaewon Lee  ;  Hae-Jeong Park  ;  Jae-Jin Kim  ;  Kee Namkoong  ;  Se Joo Kim 
Citation
 INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, Vol.83(1) : 1-7, 2012 
Journal Title
 INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY 
ISSN
 0167-8760 
Issue Date
2012
MeSH
Adolescent ; Adult ; Alpha Rhythm/physiology* ; Electroencephalography/methods ; Evoked Potentials/physiology ; Female ; Humans ; Male ; Memory Disorders/etiology* ; Memory, Short-Term/physiology* ; Neuropsychological Tests ; Obsessive-Compulsive Disorder/complications* ; Psychiatric Status Rating Scales ; Spectrum Analysis ; Verbal Learning/physiology ; Young Adult
Keywords
Obsessive compulsive disorder (OCD) ; Alpha oscillation ; Event-related desynchronization (ERD) ; Alpha phase locking ; Memory load
Abstract
Alpha event-related desynchronization (ERD) and synchronization are known to reflect brain activation and inhibition, respectively. Alpha phase locking seems to reflect the timing in the cortical process. In a previous study, lower alpha ERD was related to working memory in obsessive-compulsive disorder (OCD) patients than in controls during the retention and retrival phases, but not in the encoding phase. However, memory deficits in OCD patients are known to be related to executive failure during the encoding phase. Thus, focusing on the encoding phase, we tested the level of alpha amplitude and phase locking in OCD patients according to memory load. The EEGs of fifteen OCD patients and fifteen controls were recorded during a Sternberg working memory task. The behavioral performance of the OCD patients was normal. However, the OCD group yielded significantly lower ERD and stronger phase locking. As memory load rose, ERD and phase locking significantly increased in both groups. A difference in event-related alpha oscillation was observed in the encoding phase. Lower alpha modulation in the OCD patient simplied abnormality of the excitatory/inhibitory process in the brain, and increased phase locking might reflect excessive attentional excitability.
Full Text
http://www.sciencedirect.com/science/article/pii/S0167876011002807
DOI
21963527
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
Park, Jin Young(박진영) ORCID logo https://orcid.org/0000-0002-5351-9549
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90524
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