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Alpha amplitude and phase locking in obsessive-compulsive disorder during working memory

DC Field Value Language
dc.contributor.author김세주-
dc.contributor.author김재진-
dc.contributor.author남궁기-
dc.contributor.author박진영-
dc.contributor.author박해정-
dc.date.accessioned2014-12-19T16:57:53Z-
dc.date.available2014-12-19T16:57:53Z-
dc.date.issued2012-
dc.identifier.issn0167-8760-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90524-
dc.description.abstractAlpha event-related desynchronization (ERD) and synchronization are known to reflect brain activation and inhibition, respectively. Alpha phase locking seems to reflect the timing in the cortical process. In a previous study, lower alpha ERD was related to working memory in obsessive-compulsive disorder (OCD) patients than in controls during the retention and retrival phases, but not in the encoding phase. However, memory deficits in OCD patients are known to be related to executive failure during the encoding phase. Thus, focusing on the encoding phase, we tested the level of alpha amplitude and phase locking in OCD patients according to memory load. The EEGs of fifteen OCD patients and fifteen controls were recorded during a Sternberg working memory task. The behavioral performance of the OCD patients was normal. However, the OCD group yielded significantly lower ERD and stronger phase locking. As memory load rose, ERD and phase locking significantly increased in both groups. A difference in event-related alpha oscillation was observed in the encoding phase. Lower alpha modulation in the OCD patient simplied abnormality of the excitatory/inhibitory process in the brain, and increased phase locking might reflect excessive attentional excitability.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAlpha Rhythm/physiology*-
dc.subject.MESHElectroencephalography/methods-
dc.subject.MESHEvoked Potentials/physiology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMemory Disorders/etiology*-
dc.subject.MESHMemory, Short-Term/physiology*-
dc.subject.MESHNeuropsychological Tests-
dc.subject.MESHObsessive-Compulsive Disorder/complications*-
dc.subject.MESHPsychiatric Status Rating Scales-
dc.subject.MESHSpectrum Analysis-
dc.subject.MESHVerbal Learning/physiology-
dc.subject.MESHYoung Adult-
dc.titleAlpha amplitude and phase locking in obsessive-compulsive disorder during working memory-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Nuclear Medicine (핵의학)-
dc.contributor.googleauthorJin Young Park-
dc.contributor.googleauthorJaewon Lee-
dc.contributor.googleauthorHae-Jeong Park-
dc.contributor.googleauthorJae-Jin Kim-
dc.contributor.googleauthorKee Namkoong-
dc.contributor.googleauthorSe Joo Kim-
dc.identifier.doi21963527-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01701-
dc.contributor.localIdA00604-
dc.contributor.localIdA00870-
dc.contributor.localIdA01240-
dc.contributor.localIdA01730-
dc.relation.journalcodeJ01155-
dc.identifier.eissn1872-7697-
dc.identifier.pmid21963527-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0167876011002807-
dc.subject.keywordObsessive compulsive disorder (OCD)-
dc.subject.keywordAlpha oscillation-
dc.subject.keywordEvent-related desynchronization (ERD)-
dc.subject.keywordAlpha phase locking-
dc.subject.keywordMemory load-
dc.contributor.alternativeNameKim, Se Joo-
dc.contributor.alternativeNameKim, Jae Jin-
dc.contributor.alternativeNameNamkoong, Kee-
dc.contributor.alternativeNamePark, Jin Young-
dc.contributor.alternativeNamePark, Hae Jeong-
dc.contributor.affiliatedAuthorPark, Jin Young-
dc.contributor.affiliatedAuthorKim, Se Joo-
dc.contributor.affiliatedAuthorKim, Jae Jin-
dc.contributor.affiliatedAuthorNamkoong, Kee-
dc.contributor.affiliatedAuthorPark, Hae Jeong-
dc.citation.volume83-
dc.citation.number1-
dc.citation.startPage1-
dc.citation.endPage7-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, Vol.83(1) : 1-7, 2012-
dc.identifier.rimsid32816-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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