Biological evaluation of micro-nanoporous layer on Ti―Ag alloy for dental implant

Abstract

This study examined the biocompatibility of the micro-nanoporous layer formed on a titanium-silver (Ti-Ag) alloy. The porous layer was formed by grit-blasting and anodic oxidation. The surface of the porous layer was rougher and more hydrophilic compared to a simple machined specimen and the expressions of bone-related genes were greater for cells grown on the porous layer compared to that of cells cultured on a control surface. Also the bone-to-plate contact rate in vivo test was significantly improved for porous layer plate compare to simple machined specimen (P < 0.05). The porous layer on Ti-Ag alloy enhanced the peri-implant bone formation at the early healing stage and it was believed that this porous layer on the Ti-Ag alloy will be suitable for dental implant applications.