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Diagnostic utility of computer tomographic enterography for patients presenting with unexplained gastrointestinal symptoms

Authors
 PARK Hana  ;  JAE JUN PARK  ;  CHANG MO MOON  ;  SUNG PIL HONG  ;  JOON SEOK LIM  ;  MYEONG JIN KIM  ;  TAE II KIM  ;  WON HO KIM  ;  JAE HEE CHEON 
Citation
 Hepato-Gastroenterology, Vol.59(118) : 1869-1873, 2012 
Journal Title
 Hepato-Gastroenterology 
ISSN
 0172-6390 
Issue Date
2012
MeSH
Adult ; Aged ; Biomarkers/blood ; C-Reactive Protein/analysis ; Chi-Square Distribution ; Female ; Gastrointestinal Diseases/blood ; Gastrointestinal Diseases/diagnostic imaging* ; Gastrointestinal Diseases/etiology ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Tomography, X-Ray Computed* ; Up-Regulation
Keywords
Adult ; Aged ; Biomarkers/blood ; C-Reactive Protein/analysis ; Chi-Square Distribution ; Female ; Gastrointestinal Diseases/blood ; Gastrointestinal Diseases/diagnostic imaging* ; Gastrointestinal Diseases/etiology ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Tomography, X-Ray Computed* ; Up-Regulation
Abstract
BACKGROUND/AIMS: Computer tomographic enterography (CTE) is gaining approval for evaluation of small bowel diseases. However, the diagnostic yields of CTE for diseases other than Crohn's disease have not yet been well elucidated. The aim of the present study was to determine the diagnostic utility of CTE and to ascertain the clinical factors predictive of the positive diagnostic rate in patients with unexplained gastrointestinal symptoms or signs. METHODOLOGY: The clinical and radiological data of 193 patients with unexplained gastrointestinal symptoms that had a CTE examination at Severance Hospital between May 2007 and April 2010 were retrospectively analyzed. RESULTS: CTE revealed positive findings that explained the symptoms in 51 of the 193 patients (diagnostic yield 26.4%). Positive findings of diagnosis included cancer (12 patients), Crohn's disease (10), intestinal stricture/obstruction (9), small bowel bleeding (7), colitis (6), intestinal Behcet's disease (4), intestinal tuberculosis (2) and intestinal fistula (1). According to univariate analysis, the positive findings of CTE were significantly associated with higher segmentated neutrophil count (p<0.001), higher erythrocyte sedimentation rate (ESR) (p=0.003), higher C-reactive protein (CRP) level (p=0.008) and lower serum albumin level (p=0.037). Multivariate analysis indicated that elevated CRP level was a significant risk factor for the positive findings of CTE (odds ratio 1.950; 95% CI (1.165-3.265), p=0.011). CONCLUSIONS: The results of this study suggest that CTE could be helpful in patients suffering from unexplained gastrointestinal symptoms that cannot be explained by established examinations, especially those with elevated C-reactive protein levels.
Full Text
http://cat.inist.fr/?aModele=afficheN&cpsidt=26313239
DOI
22819907
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Moon, Chang Mo(문창모)
Park, Jae Jun(박재준)
Park, Ha Na(박하나)
Lim, Joon Seok(임준석) ORCID logo https://orcid.org/0000-0002-0334-5042
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
Hong, Sung Pil(홍성필)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90351
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