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Role of insulin-like growth factor-II mRNA-binding protein-3 in invadopodia formation and the growth of oral squamous cell carcinoma in athymic nude mice.

Authors
 Young Sun Hwang  ;  Kwang-Kyun Park  ;  In Ho Cha  ;  Jin Kim  ;  Won-Yoon Chung 
Citation
 HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.34(9) : 1329-1339, 2012 
Journal Title
 HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 
ISSN
 1043-3074 
Issue Date
2012
MeSH
Animals ; Blotting, Western ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism* ; Cell Line, Tumor ; Cells, Cultured ; Extracellular Matrix/metabolism* ; Extracellular Matrix/pathology ; Humans ; Immunohistochemistry ; Insulin-Like Growth Factor Binding Protein 3/genetics ; Insulin-Like Growth Factor Binding Protein 3/metabolism* ; Mice ; Mice, Nude ; Mouth Neoplasms/genetics ; Mouth Neoplasms/metabolism* ; RNA, Messenger/metabolism ; Real-Time Polymerase Chain Reaction ; Signal Transduction ; Transplantation, Heterologous
Keywords
invadopodia ; oral squamous cell carcinoma ; insulin-like growth factor-II mRNA-binding protein-3 ; MMPs ; matrixdegradation
Abstract
BACKGROUND: The invadopodia are specialized structures that degrade the extracellular matrix (ECM) and promote cell invasion and metastasis. Understanding the forms and functions of invadopodia should facilitate the proper identification of novel targets for antiinvasive therapy. METHODS: To understand the role of insulin-like growth factor-II mRNA-binding protein-3 (IMP-3) in invadopodia formation and cancer invasion, we performed IMP-3 gene silencing, invadopodia formation, ECM degradation assay, zymography, western blot, and mouse xenograft. RESULTS: We demonstrate that invadopodia evidenced ECM degradation activity in oral squamous cell carcinoma (OSCC). Downregulation of IMP-3 inhibited invadopodia formation, ECM degradation, and tumor growth and invasiveness. Epidermal growth factor receptor (EGFR) signaling may perform a critical function in invadopodia formation, ECM degradation, IMP-3, and cortactin expression. CONCLUSION: IMP-3 may be intimately correlated with cancer invasion through invadopodia in oral cancer. The overexpression of IMP-3 in oral cancer was predictive of a high correlation with cancer growth and invasion.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/hed.21929/abstract
DOI
22052854
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin(김진)
Park, Kwang Kyun(박광균)
Chung, Won Yoon(정원윤) ORCID logo https://orcid.org/0000-0001-8428-9005
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
Hwang, Young Sun(황영선)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90335
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