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Role of insulin-like growth factor-II mRNA-binding protein-3 in invadopodia formation and the growth of oral squamous cell carcinoma in athymic nude mice.

DC FieldValueLanguage
dc.contributor.author김진-
dc.contributor.author박광균-
dc.contributor.author정원윤-
dc.contributor.author차인호-
dc.contributor.author황영선-
dc.date.accessioned2014-12-19T16:51:46Z-
dc.date.available2014-12-19T16:51:46Z-
dc.date.issued2012-
dc.identifier.issn1043-3074-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90335-
dc.description.abstractBACKGROUND: The invadopodia are specialized structures that degrade the extracellular matrix (ECM) and promote cell invasion and metastasis. Understanding the forms and functions of invadopodia should facilitate the proper identification of novel targets for antiinvasive therapy. METHODS: To understand the role of insulin-like growth factor-II mRNA-binding protein-3 (IMP-3) in invadopodia formation and cancer invasion, we performed IMP-3 gene silencing, invadopodia formation, ECM degradation assay, zymography, western blot, and mouse xenograft. RESULTS: We demonstrate that invadopodia evidenced ECM degradation activity in oral squamous cell carcinoma (OSCC). Downregulation of IMP-3 inhibited invadopodia formation, ECM degradation, and tumor growth and invasiveness. Epidermal growth factor receptor (EGFR) signaling may perform a critical function in invadopodia formation, ECM degradation, IMP-3, and cortactin expression. CONCLUSION: IMP-3 may be intimately correlated with cancer invasion through invadopodia in oral cancer. The overexpression of IMP-3 in oral cancer was predictive of a high correlation with cancer growth and invasion.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfHead & Neck-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBlotting, Western-
dc.subject.MESHCarcinoma, Squamous Cell/genetics-
dc.subject.MESHCarcinoma, Squamous Cell/metabolism*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCells, Cultured-
dc.subject.MESHExtracellular Matrix/metabolism*-
dc.subject.MESHExtracellular Matrix/pathology-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHInsulin-Like Growth Factor Binding Protein 3/genetics-
dc.subject.MESHInsulin-Like Growth Factor Binding Protein 3/metabolism*-
dc.subject.MESHMice-
dc.subject.MESHMice, Nude-
dc.subject.MESHMouth Neoplasms/genetics-
dc.subject.MESHMouth Neoplasms/metabolism*-
dc.subject.MESHRNA, Messenger/metabolism-
dc.subject.MESHReal-Time Polymerase Chain Reaction-
dc.subject.MESHSignal Transduction-
dc.subject.MESHTransplantation, Heterologous-
dc.titleRole of insulin-like growth factor-II mRNA-binding protein-3 in invadopodia formation and the growth of oral squamous cell carcinoma in athymic nude mice.-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorYoung Sun Hwang-
dc.contributor.googleauthorKwang-Kyun Park-
dc.contributor.googleauthorIn Ho Cha-
dc.contributor.googleauthorJin Kim-
dc.contributor.googleauthorWon-Yoon Chung-
dc.identifier.doi22052854-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01429-
dc.contributor.localIdA03676-
dc.contributor.localIdA04472-
dc.contributor.localIdA01009-
dc.contributor.localIdA04002-
dc.relation.journalcodeJ00963-
dc.identifier.pmid22052854-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/hed.21929/abstract-
dc.subject.keywordinvadopodia-
dc.subject.keywordoral squamous cell carcinoma-
dc.subject.keywordinsulin-like growth factor-II mRNA-binding protein-3-
dc.subject.keywordMMPs-
dc.subject.keywordmatrixdegradation-
dc.contributor.alternativeNameKim, Jin-
dc.contributor.alternativeNamePark, Kwang Kyun-
dc.contributor.alternativeNameChung, Won Yoon-
dc.contributor.alternativeNameCha, In Ho-
dc.contributor.alternativeNameHwang, Young Sun-
dc.contributor.affiliatedAuthorPark, Kwang Kyun-
dc.contributor.affiliatedAuthorChung, Won Yoon-
dc.contributor.affiliatedAuthorHwang, Young Sun-
dc.contributor.affiliatedAuthorKim, Jin-
dc.contributor.affiliatedAuthorCha, In Ho-
dc.citation.volume34-
dc.citation.number9-
dc.citation.startPage1329-
dc.citation.endPage1339-
dc.identifier.bibliographicCitationHead & Neck, Vol.34(9) : 1329-1339, 2012-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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