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Hyperintense HCC on hepatobiliary phase images of gadoxetic acid-enhanced MRI: Correlation with clinical and pathological features

Authors
 Ja Young Kim  ;  Myeong-Jin Kim  ;  Kyung Ah Kim  ;  Hyeon Tae Jeong  ;  Young Nyun Park 
Citation
 EUROPEAN JOURNAL OF RADIOLOGY, Vol.81(12) : 3877-3882, 2012 
Journal Title
 EUROPEAN JOURNAL OF RADIOLOGY 
ISSN
 0720-048X 
Issue Date
2012
MeSH
Adult ; Aged ; Aged, 80 and over ; Algorithms* ; Carcinoma, Hepatocellular/pathology* ; Contrast Media ; Female ; Gadolinium DTPA* ; Humans ; Image Enhancement/methods ; Image Interpretation, Computer-Assisted/methods* ; Liver Neoplasms/pathology* ; Magnetic Resonance Imaging/methods* ; Male ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity
Keywords
Hepatocellular carcinoma ; Gadoxetate disodium (Gd-EOB-DTPA) ; Pathology ; Prognosis ; Surgery
Abstract
PURPOSE: To retrospectively determine whether the hyperintense hepatocellular carcinomas (HCCs) seen on the hepatobiliary phase of gadoxetic acid-enhanced MR imaging (EOB-MRI) might have different histologic characteristics from usual hypointense HCCs. MATERIALS AND METHODS: Two hundred three surgically proven HCCs from 192 patients who underwent preoperative EOB-MRI were analyzed. The demographic and histologic characteristics of hyperintense HCCs were compared with usual hypointense HCCs by using the t-test or Fisher's exact test. RESULTS: By visual assessment, 18 (8.8%) tumors were classified as hyperintense HCCs. Patients with hyperintense HCC were significantly (p<0.05) older (60.1 vs. 55.2 years) than those with hypointense HCCs. Hyperintense HCCs showed significantly lower rate of microvascular invasion (27.8% vs. 53.5%) and significantly higher rate of peliosis (61.1% vs. 30.8%). Hyperintense HCCs were more frequently expanding type, and none showed infiltrative type or scirrhous histologic pattern. CONCLUSIONS: Hyperintense HCCs seem to have clinical and histologic features that might be related with more favorable outcomes.
Full Text
http://www.sciencedirect.com/science/article/pii/S0720048X12003907
DOI
22954410
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Ah(김경아)
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Kim, Ja Young(김자영)
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90240
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