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Uterine artery embolization (UAE) for diffuse leiomyomatosis of the uterus: clinical and imaging results.

Authors
 Jieun Koh  ;  Man Deuk Kim  ;  Dae Chul Jung  ;  Myungsu Lee  ;  Mu Sook Lee  ;  Jong Yun Won  ;  Do Yun Lee  ;  Sung Il Park  ;  Kwang Hun Lee 
Citation
 European Journal of Radiology, Vol.81(10) : 2726-2729, 2012 
Journal Title
 European Journal of Radiology 
ISSN
 0720-048X 
Issue Date
2012
MeSH
Adult ; Female ; Humans ; Leiomyomatosis/epidemiology ; Leiomyomatosis/pathology* ; Leiomyomatosis/therapy* ; Magnetic Resonance Imaging/statistics & numerical data* ; Prevalence ; Prognosis ; Republic of Korea/epidemiology ; Treatment Outcome ; Uterine Artery Embolization/statistics & numerical data* ; Uterine Neoplasms/epidemiology ; Uterine Neoplasms/pathology* ; Uterine Neoplasms/therapy*
Keywords
Leiomyomatosis ; Uterine artery embolization ; MRI
Abstract
PURPOSE: The aim of the current study was to evaluate the efficacy of uterine artery embolization (UAE) in the management of diffuse uterine leiomyomatosis with mid-term follow-up. MATERIALS AND METHODS: All patients who underwent UAE between 2008 and 2010 for symptomatic fibroids were analyzed. Among 360 cases, a total of 7 patients with diffuse uterine leiomyomatosis diagnosed based on MRI were included in this retrospective study. Patient ages ranged from 29 to 38 (mean 32.7) years. The median follow-up period was 16 (range; 6-31) months. The embolic agent was non-spherical polyvinyl alcohol particles. All patients underwent follow-up MRI at 3 months after UAE. Uterine volumes were calculated using MRI. Menorrhagia symptom changes were assessed at mid-term follow-up. RESULTS: There were no technical failures to catheterize the uterine artery and no adverse events requiring therapy after UAE. Contrast-enhanced MRI showed complete necrosis of the leiomyomatous nodules in 5 patients (71%) 3 months after embolization. Two patients (28%) showed mostly leiomyomatous nodules that were necrotized, some of which were still viable. All 7 patients with menorrhagia had improvement of symptoms at the mid-term follow-up. The initial mean uterine volume was 601.30 ± 533.92 cm(3) and was decreased to a mean of 278.81 ± 202.70 cm(3) at 3 months follow-up, for a mean uterus volume reduction rate of 50.1% (p<0.05). One patient became pregnant 5 months after UAE treatment. CONCLUSION: UAE was a highly effective treatment for diffuse uterine leiomyomatosis with mid-term durability and may be a valuable alternative to hysterectomy.
Full Text
http://www.sciencedirect.com/science/article/pii/S0720048X11007868
DOI
22154588
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Man Deuk(김만득) ORCID logo https://orcid.org/0000-0002-3575-5847
Park, Sung Il(박성일)
Won, Jong Yun(원종윤) ORCID logo https://orcid.org/0000-0002-8237-5628
Lee, Kwang Hun(이광훈)
Lee, Do Yun(이도연)
Lee, Myung Su(이명수)
Lee, Mu Sook(이무숙)
Jung, Dae Chul(정대철) ORCID logo https://orcid.org/0000-0001-5769-5083
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90229
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