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Development of hepatocellular carcinomas in patients with absence of tumors on a prior ultrasound examination.

Authors
 Kyung Ah Kim ; Myeong-Jin Kim ; Yong Eun Chung ; Jin-Young Choi 
Citation
 European Journal of Radiology, Vol.81(7) : 1450~1454, 2012 
Journal Title
 European Journal of Radiology 
ISSN
 0720-048X 
Issue Date
2012
Abstract
BACKGROUND: To evaluate hepatocellular carcinoma (HCC) that developed in patients with no evidence of a tumor during a prior ultrasound (US) performed within 1 year of the diagnosis. METHODS: We retrospectively analyzed data for 100 consecutive patients with liver cirrhosis who had undergone US within 1 year prior to HCC diagnosis and who showed no liver lesions on the previous US. Size and T stage of HCC were assessed as well as whether patients met surgical criteria for liver transplantation as HCC treatment [Milan or University of California at San Francisco (UCSF) criteria]. RESULTS: The mean interval between the negative and diagnostic scans was 5 months, 13 days. HCC presented as a single nodule in 69 patients (size, 0.8-8.0 cm), as two or more nodules in 18 patients, and as the diffuse form of HCC in 13 patients. HCC presented as a small tumor (<3 cm) in 48 patients. T stages were: T1 in 26 patients, T2 in 45, T3 in 18, and T4 in 11. The Milan criteria were met in 79 patients. Eighty-five patients fulfilled the UCSF. CONCLUSION: Patients may present with advanced HCC, even if sonographic findings were negative within 1 year prior to diagnosis.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90228
DOI
10.1016/j.ejrad.2011.03.053
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0720048X11003238
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