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Clinical characteristics and prognosis of hepatocellular carcinoma with different sets of serum AFP and PIVKA-II levels.

Authors
 Se Hun Kang  ;  Do Young Kim  ;  Soung Min Jeon  ;  Sang Hoon Ahn  ;  Jun Yong Park  ;  Seung Up Kim  ;  Ja Kyung Kim  ;  Kwan Sik Lee  ;  Chae Yoon Chon  ;  Kwang-Hyub Han 
Citation
 EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, Vol.24(7) : 849-856, 2012 
Journal Title
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
ISSN
 0954-691X 
Issue Date
2012
MeSH
Adult ; Aged ; Biomarkers/blood* ; Biomarkers, Tumor/blood* ; Carcinoma, Hepatocellular/diagnosis* ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/therapy ; Female ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/diagnosis* ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Male ; Middle Aged ; Neoplasm Proteins/blood ; Neoplasm Staging ; Prognosis ; Protein Precursors/blood* ; Prothrombin ; Treatment Outcome ; alpha-Fetoproteins/analysis*
Keywords
a-Fetoprotein ; hepatocellular carcinoma ; prothrombin induced by vitamin K absence or antagonist-II ; survival
Abstract
OBJECTIVE: α-Fetoprotein (AFP) and prothrombin induced by the absence of vitamin K or antagonist-II (PIVKA-II) are useful tumor markers for hepatocellular carcinoma (HCC). However, little is known about the clinical characteristics and prognosis of HCC with different levels of AFP and PIVKA-II.

METHODS: Consecutive 1447 HCC patients were assigned to four groups according to the cutoff values of AFP (400 ng/ml) and PIVKA-II (100 mAU/ml): both values high (AP), one of the values high (Ap and aP), and both values low (ap). The clinical characteristics and the prognosis of group ap were compared with those of the other groups.

RESULTS: HCC patients in group ap were more asymptomatic at diagnosis, and had smaller size, fewer numbers, and earlier stages of HCC, and more preserved liver functions (all, P<0.001). The survival rate of group ap was significantly higher than those of the other groups (P<0.001). In multivariate analysis, the combined status of AFP and PIVKA-II values were independent predictors for survival (P<0.001), together with tumor size, number, portal vein thrombosis, Child-Pugh class, and treatment modality.

CONCLUSION: HCC patients with low values of both AFP and PIVKA-II had more favorable clinical characteristics and showed a better prognosis than those with elevated levels of AFP or PIVKA-II.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00042737-201207000-00018&LSLINK=80&D=ovft
DOI
22495400
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Se Hun(강세훈)
Kim, Do Young(김도영)
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Kim, Ja Kyung(김자경) ORCID logo https://orcid.org/0000-0001-5025-6846
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Jeon, Soung Min(전승민)
Chon, Chae Yoon(전재윤)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90199
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