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Clinical characteristics and prognosis of hepatocellular carcinoma with different sets of serum AFP and PIVKA-II levels.

DC FieldValueLanguage
dc.contributor.author강세훈-
dc.contributor.author김도영-
dc.contributor.author김승업-
dc.contributor.author김자경-
dc.contributor.author박준용-
dc.contributor.author안상훈-
dc.contributor.author이관식-
dc.contributor.author전승민-
dc.contributor.author전재윤-
dc.contributor.author한광협-
dc.date.accessioned2014-12-19T16:47:27Z-
dc.date.available2014-12-19T16:47:27Z-
dc.date.issued2012-
dc.identifier.issn0954-691X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90199-
dc.description.abstractOBJECTIVE: α-Fetoprotein (AFP) and prothrombin induced by the absence of vitamin K or antagonist-II (PIVKA-II) are useful tumor markers for hepatocellular carcinoma (HCC). However, little is known about the clinical characteristics and prognosis of HCC with different levels of AFP and PIVKA-II. METHODS: Consecutive 1447 HCC patients were assigned to four groups according to the cutoff values of AFP (400 ng/ml) and PIVKA-II (100 mAU/ml): both values high (AP), one of the values high (Ap and aP), and both values low (ap). The clinical characteristics and the prognosis of group ap were compared with those of the other groups. RESULTS: HCC patients in group ap were more asymptomatic at diagnosis, and had smaller size, fewer numbers, and earlier stages of HCC, and more preserved liver functions (all, P<0.001). The survival rate of group ap was significantly higher than those of the other groups (P<0.001). In multivariate analysis, the combined status of AFP and PIVKA-II values were independent predictors for survival (P<0.001), together with tumor size, number, portal vein thrombosis, Child-Pugh class, and treatment modality. CONCLUSION: HCC patients with low values of both AFP and PIVKA-II had more favorable clinical characteristics and showed a better prognosis than those with elevated levels of AFP or PIVKA-II.-
dc.description.statementOfResponsibilityopen-
dc.format.extent849~856-
dc.relation.isPartOfEuropean Journal of Gastroenterology & Hepatology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleClinical characteristics and prognosis of hepatocellular carcinoma with different sets of serum AFP and PIVKA-II levels.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSe Hun Kang-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorSoung Min Jeon-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorJa Kyung Kim-
dc.contributor.googleauthorKwan Sik Lee-
dc.contributor.googleauthorChae Yoon Chon-
dc.contributor.googleauthorKwang-Hyub Han-
dc.identifier.doi10.1097/MEG.0b013e3283535c34-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00043-
dc.contributor.localIdA00654-
dc.contributor.localIdA00852-
dc.contributor.localIdA01675-
dc.contributor.localIdA02226-
dc.contributor.localIdA02666-
dc.contributor.localIdA03526-
dc.contributor.localIdA04268-
dc.contributor.localIdA03544-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ00821-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00042737-201207000-00018&LSLINK=80&D=ovft-
dc.contributor.alternativeNameKang, Se Hun-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNameKim, Ja Kyung-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameLee, Kwan Sik-
dc.contributor.alternativeNameJeon, Soung Min-
dc.contributor.alternativeNameChon, Chae Yoon-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKang, Se Hun-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorKim, Ja Kyung-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorLee, Kwan Sik-
dc.contributor.affiliatedAuthorJeon, Soung Min-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorChon, Chae Yoon-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.citation.volume24-
dc.citation.number7-
dc.citation.startPage849-
dc.citation.endPage856-
dc.identifier.bibliographicCitationEuropean Journal of Gastroenterology & Hepatology, Vol.24(7) : 849-856, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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