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Correlation between soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) expression and endoscopic activity in inflammatory bowel diseases.

 Yoon Suk Jung  ;  Jae Jun Park  ;  Seung Won Kim  ;  Sung Pil Hong  ;  Tae Il Kim  ;  Won Ho Kim  ;  Jae Hee Cheon 
 DIGESTIVE AND LIVER DISEASE, Vol.44(11) : 897-903, 2012 
Journal Title
Issue Date
Adolescent ; Adult ; Biomarkers/blood ; Blood Sedimentation ; C-Reactive Protein/analysis ; Colitis, Ulcerative/blood ; Colitis, Ulcerative/pathology ; Crohn Disease/blood ; Crohn Disease/pathology ; Endoscopy, Digestive System ; Female ; Humans ; Inflammatory Bowel Diseases*/blood ; Inflammatory Bowel Diseases*/pathology ; Male ; Membrane Glycoproteins/blood* ; Membrane Glycoproteins/metabolism ; Middle Aged ; Prospective Studies ; Receptors, Immunologic/blood* ; Receptors, Immunologic/metabolism ; Sensitivity and Specificity ; Severity of Illness Index ; Triggering Receptor Expressed on Myeloid Cells-1
C-reactive protein ; Crohn's disease ; Endoscopic activity ; Erythrocyte sedimentation rate ; Triggering receptor expressed on myeloid cells-1 ; Ulcerative colitis
BACKGROUND: Recently, a triggering receptor expressed on myeloid cells-1 was shown to be upregulated in the intestines of patients with inflammatory bowel diseases.

AIMS: To investigate the relationship between serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) level and endoscopic activity in patients with inflammatory bowel diseases.

METHODS: A total of 85 patients with ulcerative colitis and 34 patients with Crohn's disease were prospectively enrolled. Endoscopic disease activity was determined using the Mayo score and the Simplified Endoscopic Activity Score for Crohn's disease.

RESULTS: In ulcerative colitis, sTREM-1 level was correlated more strongly with the endoscopic activity (r=0.498) than the C-reactive protein level (r=0.386) or erythrocyte sedimentation rate (r=0.272), although not superior to the partial Mayo score (r=0.611). Moreover, only sTREM-1 was correlated significantly with the endoscopic activity irrespective of the disease extent. In Crohn's disease, the Simplified Endoscopic Activity Score for Crohn's disease was correlated with both the C-reactive protein level (r=0.585) and erythrocyte sedimentation rate (r=0.474), but not with sTREM-1 level (r=0.097).

CONCLUSIONS: In ulcerative colitis, sTREM-1 level was correlated most closely with the endoscopic disease activity among serum biomarkers, but was not superior to the clinical activity index. Our results suggest that sTREM-1 level may represent a complementary marker for the assessment of endoscopic activity in ulcerative colitis, but not in Crohn's disease.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
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Yonsei Authors
Kim, Seung Won(김승원) ORCID logo https://orcid.org/0000-0002-1692-1192
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Park, Jae Jun(박재준)
Jung, Yoon Suk(정윤숙)
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
Hong, Sung Pil(홍성필)
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