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Correlation between soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) expression and endoscopic activity in inflammatory bowel diseases.

DC FieldValueLanguage
dc.contributor.author김태일-
dc.contributor.author박재준-
dc.contributor.author정윤숙-
dc.contributor.author천재희-
dc.contributor.author홍성필-
dc.contributor.author김승원-
dc.contributor.author김원호-
dc.date.accessioned2014-12-19T16:45:29Z-
dc.date.available2014-12-19T16:45:29Z-
dc.date.issued2012-
dc.identifier.issn1590-8658-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90137-
dc.description.abstractBACKGROUND: Recently, a triggering receptor expressed on myeloid cells-1 was shown to be upregulated in the intestines of patients with inflammatory bowel diseases. AIMS: To investigate the relationship between serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) level and endoscopic activity in patients with inflammatory bowel diseases. METHODS: A total of 85 patients with ulcerative colitis and 34 patients with Crohn's disease were prospectively enrolled. Endoscopic disease activity was determined using the Mayo score and the Simplified Endoscopic Activity Score for Crohn's disease. RESULTS: In ulcerative colitis, sTREM-1 level was correlated more strongly with the endoscopic activity (r=0.498) than the C-reactive protein level (r=0.386) or erythrocyte sedimentation rate (r=0.272), although not superior to the partial Mayo score (r=0.611). Moreover, only sTREM-1 was correlated significantly with the endoscopic activity irrespective of the disease extent. In Crohn's disease, the Simplified Endoscopic Activity Score for Crohn's disease was correlated with both the C-reactive protein level (r=0.585) and erythrocyte sedimentation rate (r=0.474), but not with sTREM-1 level (r=0.097). CONCLUSIONS: In ulcerative colitis, sTREM-1 level was correlated most closely with the endoscopic disease activity among serum biomarkers, but was not superior to the clinical activity index. Our results suggest that sTREM-1 level may represent a complementary marker for the assessment of endoscopic activity in ulcerative colitis, but not in Crohn's disease.-
dc.description.statementOfResponsibilityopen-
dc.format.extent897~903-
dc.relation.isPartOfDIGESTIVE AND LIVER DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHBlood Sedimentation-
dc.subject.MESHC-Reactive Protein/analysis-
dc.subject.MESHColitis, Ulcerative/blood-
dc.subject.MESHColitis, Ulcerative/pathology-
dc.subject.MESHCrohn Disease/blood-
dc.subject.MESHCrohn Disease/pathology-
dc.subject.MESHEndoscopy, Digestive System-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInflammatory Bowel Diseases*/blood-
dc.subject.MESHInflammatory Bowel Diseases*/pathology-
dc.subject.MESHMale-
dc.subject.MESHMembrane Glycoproteins/blood*-
dc.subject.MESHMembrane Glycoproteins/metabolism-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHReceptors, Immunologic/blood*-
dc.subject.MESHReceptors, Immunologic/metabolism-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHTriggering Receptor Expressed on Myeloid Cells-1-
dc.titleCorrelation between soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) expression and endoscopic activity in inflammatory bowel diseases.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorYoon Suk Jung-
dc.contributor.googleauthorJae Jun Park-
dc.contributor.googleauthorSeung Won Kim-
dc.contributor.googleauthorSung Pil Hong-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorWon Ho Kim-
dc.contributor.googleauthorJae Hee Cheon-
dc.identifier.doi22721842-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01079-
dc.contributor.localIdA01636-
dc.contributor.localIdA03680-
dc.contributor.localIdA04404-
dc.contributor.localIdA00774-
dc.contributor.localIdA00656-
dc.contributor.localIdA04030-
dc.relation.journalcodeJ00735-
dc.identifier.eissn1878-3562-
dc.identifier.pmid22721842-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1590865812001946-
dc.subject.keywordC-reactive protein-
dc.subject.keywordCrohn's disease-
dc.subject.keywordEndoscopic activity-
dc.subject.keywordErythrocyte sedimentation rate-
dc.subject.keywordTriggering receptor expressed on myeloid cells-1-
dc.subject.keywordUlcerative colitis-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.alternativeNamePark, Jae Jun-
dc.contributor.alternativeNameJung, Yoon Suk-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.alternativeNameHong, Sung Pil-
dc.contributor.alternativeNameKim, Seung Won-
dc.contributor.alternativeNameKim, Won Ho-
dc.contributor.affiliatedAuthorKim, Tae Il-
dc.contributor.affiliatedAuthorPark, Jae Jun-
dc.contributor.affiliatedAuthorJung, Yoon Suk-
dc.contributor.affiliatedAuthorHong, Sung Pil-
dc.contributor.affiliatedAuthorKim, Won Ho-
dc.contributor.affiliatedAuthorKim, Seung Won-
dc.contributor.affiliatedAuthorCheon, Jae Hee-
dc.citation.volume44-
dc.citation.number11-
dc.citation.startPage897-
dc.citation.endPage903-
dc.identifier.bibliographicCitationDIGESTIVE AND LIVER DISEASE, Vol.44(11) : 897-903, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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