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Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction via Beta Cell ABCA1

Authors
 Hannah Seok ; Ji Young Lee ; Bong Soo Cha ; Hyun Chul Lee ; Eun Seok Kang ; Byung-Wan Lee ; Seungtaek Lim ; Jae Hyuk Lee ; Se Eun Park ; Eun Mi Park 
Citation
 Diabetes and Metabolism Journal, Vol.36(4) : 275~279, 2012 
Journal Title
 Diabetes and Metabolism Journal 
ISSN
 2233-6079 
Issue Date
2012
Abstract
BACKGROUND: The aim of this study was to investigate the effects of balsamic vinegar on β-cell dysfunction. METHODS: In this study, 28-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats were fed a normal chow diet or a high-fat diet (HFD) and were provided with tap water or dilute balsamic vinegar for 4 weeks. Oral glucose tolerance tests and histopathological analyses were performed thereafter. RESULTS: In rats fed both the both chow diet and the HFD, the rats given balsamic vinegar showed increased insulin staining in islets compared with tap water administered rats. Balsamic vinegar administration also increased β-cell ATP-binding cassette transporter subfamily A member 1 (ABCA1) expression in islets and decreased cholesterol levels. CONCLUSION: These findings provide the first evidence for an anti-diabetic effect of balsamic vinegar through improvement of β-cell function via increasing β-cell ABCA1 expression.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90113
DOI
10.4093/dmj.2012.36.4.275
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 1. College of Medicine > Medical Research Center
Yonsei Authors
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