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Prevalence and determinants of coronary artery disease in first-degree relatives of premature coronary artery disease.

 Kang, Min-Kyung  ;  Chang, Hyuk-Jae  ;  Kim, Young Jin  ;  Park, Ae Ran  ;  Park, Sungha  ;  Jang, Yangsoo  ;  Chung, Namsik 
 Coronary Artery Disease, Vol.23(3) : 167-173, 2012 
Journal Title
 Coronary Artery Disease 
Issue Date
BACKGROUND: This study aimed to investigate the prevalence of subclinical coronary artery disease (CAD) in first-degree relatives (FDRs) with premature CAD and its associating factors other than conventional risk factors. METHODS: A total of 122 FDRs (58 men, 50±7 years) of patients with premature CAD were enrolled. The individuals who had undergone health checkups were included in the control group. Multidetector coronary computed tomography was performed to detect subclinical CAD. RESULTS: The prevalence of subclinical CAD (35 vs. 14%, P<0.001) and at least 50% subclinical CAD (16 vs. 2.5%, P<0.001) was higher in FDRs than that in the control group. In conditional regression analysis, the urinary albumin-creatinine ratio showed a significant interaction with CAD in FDRs than the control (odds ratio 1.063, 95% confidence interval 1.009-1.118, P=0.021). CONCLUSION: FDRs of premature CAD are more prevalent in subclinical CAD independent of conventional risk factors. Urinary albumin-creatinine ratio may have an interaction with the development of subclinical CAD in FDRs of premature CAD.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
Yonsei Authors
강민경(Kang, Min Kyung)
박성하(Park, Sung Ha) ORCID logo https://orcid.org/0000-0001-5362-478X
박애란(Park, Ae Ran)
장양수(Jang, Yang Soo) ORCID logo https://orcid.org/0000-0002-2169-3112
장혁재(Chang, Hyuck Jae) ORCID logo https://orcid.org/0000-0002-6139-7545
정남식(Chung, Nam Sik)
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