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Prevalence and determinants of coronary artery disease in first-degree relatives of premature coronary artery disease.

Authors
 Kang, Min-Kyung ; Chang, Hyuk-Jae ; Chung, Namsik ; Jang, Yangsoo ; Park, Sungha ; Park, Ae Ran ; Kim, Young Jin 
Citation
 Coronary Artery Disease, Vol.23(3) : 167~173, 2012 
Journal Title
 Coronary Artery Disease 
ISSN
 0954-6928 
Issue Date
2012
Abstract
BACKGROUND: This study aimed to investigate the prevalence of subclinical coronary artery disease (CAD) in first-degree relatives (FDRs) with premature CAD and its associating factors other than conventional risk factors. METHODS: A total of 122 FDRs (58 men, 50±7 years) of patients with premature CAD were enrolled. The individuals who had undergone health checkups were included in the control group. Multidetector coronary computed tomography was performed to detect subclinical CAD. RESULTS: The prevalence of subclinical CAD (35 vs. 14%, P<0.001) and at least 50% subclinical CAD (16 vs. 2.5%, P<0.001) was higher in FDRs than that in the control group. In conditional regression analysis, the urinary albumin-creatinine ratio showed a significant interaction with CAD in FDRs than the control (odds ratio 1.063, 95% confidence interval 1.009-1.118, P=0.021). CONCLUSION: FDRs of premature CAD are more prevalent in subclinical CAD independent of conventional risk factors. Urinary albumin-creatinine ratio may have an interaction with the development of subclinical CAD in FDRs of premature CAD.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/90075
DOI
10.1097/MCA.0b013e3283515538
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 1. College of Medicine > Medical Research Center
Yonsei Authors
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Link
 http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00019501-201205000-00005&LSLINK=80&D=ovft
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