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The ratio of glycated albumin to glycated haemoglobin correlates with insulin secretory function.

Authors
 Daham Kim  ;  Kwang J. Kim  ;  Ji H. Huh  ;  Byung-Wan Lee  ;  Eun S. Kang  ;  Bong S. Cha  ;  Hyun C. Lee 
Citation
 CLINICAL ENDOCRINOLOGY, Vol.77(5) : 679-683, 2012 
Journal Title
 CLINICAL ENDOCRINOLOGY 
ISSN
 0300-0664 
Issue Date
2012
MeSH
Aged ; Female ; Glycated Hemoglobin A/metabolism* ; Humans ; Insulin/secretion* ; Male ; Middle Aged ; Retrospective Studies ; Serum Albumin/metabolism*
Keywords
Aged ; Female ; Glycated Hemoglobin A/metabolism* ; Humans ; Insulin/secretion* ; Male ; Middle Aged ; Retrospective Studies ; Serum Albumin/metabolism*
Abstract
OBJECTIVE: Although glycated haemoglobin (A1c) levels are similar among patients with type 2 diabetes, the glycated albumin (GA)/A1c ratio varies considerably. On the basis of the hypothesis that endogenous insulin secretion might be correlated with the GA/A1c ratio, we investigated whether insulin secretory function or insulin resistance has different effects on the GA/A1c ratio in patients with type 2 diabetes using the standardized liquid meal test. DESIGN: A clinical, retrospective study. PATIENTS AND MEASUREMENTS: A total of 758 patients with type 2 diabetes ingested a standardized liquid meal (i.e. 500 kcal, 17·5 g fat, 68·5 g carbohydrate and 17·5 g protein). The subjects were divided into two groups: those with GA/A1c ratio <2·5 (n = 414) and those with GA/A1c ratio ≥2·5 (n = 344). We compared the A1c and GA levels, and the GA/A1c ratio and evaluated the relationships between the glycaemic indices and other parameters. Effects of β-cell function [homeostasis model assessment (HOMA-β), insulinogenic index (IGI)] and insulin resistance (HOMA-IR) on the GA/A1c ratio were also examined. RESULTS: The GA/A1c ratio was significantly correlated with HOMA-β, IGI and body mass index (BMI) but not with HOMA-IR. Furthermore, after adjusting for age, gender, BMI, haemoglobin and albumin levels, the GA/A1c ratio was still inversely correlated with both HOMA-β and IGI. CONCLUSIONS: The GA/A1c ratio is significantly correlated with insulin secretory function but not with insulin resistance.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2011.04312.x/abstract
DOI
22150917
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kwang Joon(김광준) ORCID logo https://orcid.org/0000-0002-5554-8255
Kim, Daham(김다함) ORCID logo https://orcid.org/0000-0003-1871-686X
Lee, Byung Wan(이병완) ORCID logo https://orcid.org/0000-0002-9899-4992
Lee, Hyun Chul(이현철)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
Huh, Ji Hye(허지혜)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90017
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