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The ratio of glycated albumin to glycated haemoglobin correlates with insulin secretory function.

DC FieldValueLanguage
dc.contributor.author허지혜-
dc.contributor.author강은석-
dc.contributor.author김다함-
dc.contributor.author이병완-
dc.contributor.author이현철-
dc.contributor.author차봉수-
dc.contributor.author김광준-
dc.date.accessioned2014-12-19T16:41:47Z-
dc.date.available2014-12-19T16:41:47Z-
dc.date.issued2012-
dc.identifier.issn0300-0664-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90017-
dc.description.abstractOBJECTIVE: Although glycated haemoglobin (A1c) levels are similar among patients with type 2 diabetes, the glycated albumin (GA)/A1c ratio varies considerably. On the basis of the hypothesis that endogenous insulin secretion might be correlated with the GA/A1c ratio, we investigated whether insulin secretory function or insulin resistance has different effects on the GA/A1c ratio in patients with type 2 diabetes using the standardized liquid meal test. DESIGN: A clinical, retrospective study. PATIENTS AND MEASUREMENTS: A total of 758 patients with type 2 diabetes ingested a standardized liquid meal (i.e. 500 kcal, 17·5 g fat, 68·5 g carbohydrate and 17·5 g protein). The subjects were divided into two groups: those with GA/A1c ratio <2·5 (n = 414) and those with GA/A1c ratio ≥2·5 (n = 344). We compared the A1c and GA levels, and the GA/A1c ratio and evaluated the relationships between the glycaemic indices and other parameters. Effects of β-cell function [homeostasis model assessment (HOMA-β), insulinogenic index (IGI)] and insulin resistance (HOMA-IR) on the GA/A1c ratio were also examined. RESULTS: The GA/A1c ratio was significantly correlated with HOMA-β, IGI and body mass index (BMI) but not with HOMA-IR. Furthermore, after adjusting for age, gender, BMI, haemoglobin and albumin levels, the GA/A1c ratio was still inversely correlated with both HOMA-β and IGI. CONCLUSIONS: The GA/A1c ratio is significantly correlated with insulin secretory function but not with insulin resistance.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfCLINICAL ENDOCRINOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHFemale-
dc.subject.MESHGlycated Hemoglobin A/metabolism*-
dc.subject.MESHHumans-
dc.subject.MESHInsulin/secretion*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSerum Albumin/metabolism*-
dc.titleThe ratio of glycated albumin to glycated haemoglobin correlates with insulin secretory function.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorDaham Kim-
dc.contributor.googleauthorKwang J. Kim-
dc.contributor.googleauthorJi H. Huh-
dc.contributor.googleauthorByung-Wan Lee-
dc.contributor.googleauthorEun S. Kang-
dc.contributor.googleauthorBong S. Cha-
dc.contributor.googleauthorHyun C. Lee-
dc.identifier.doi22150917-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04368-
dc.contributor.localIdA00068-
dc.contributor.localIdA02796-
dc.contributor.localIdA03301-
dc.contributor.localIdA03996-
dc.contributor.localIdA00363-
dc.contributor.localIdA00317-
dc.relation.journalcodeJ00571-
dc.identifier.eissn1365-2265-
dc.identifier.pmid22150917-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2011.04312.x/abstract-
dc.subject.keywordAged-
dc.subject.keywordFemale-
dc.subject.keywordGlycated Hemoglobin A/metabolism*-
dc.subject.keywordHumans-
dc.subject.keywordInsulin/secretion*-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordRetrospective Studies-
dc.subject.keywordSerum Albumin/metabolism*-
dc.contributor.alternativeNameHuh, Ji Hye-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameKim, Da Ham-
dc.contributor.alternativeNameLee, Byung Wan-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.affiliatedAuthorHuh, Ji Hye-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.contributor.affiliatedAuthorLee, Byung Wan-
dc.contributor.affiliatedAuthorLee, Hyun Chul-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.contributor.affiliatedAuthorKim, Da Ham-
dc.contributor.affiliatedAuthorKim, Kwang Joon-
dc.citation.volume77-
dc.citation.number5-
dc.citation.startPage679-
dc.citation.endPage683-
dc.identifier.bibliographicCitationCLINICAL ENDOCRINOLOGY, Vol.77(5) : 679-683, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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