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The ratio of glycated albumin to glycated haemoglobin correlates with insulin secretory function.
DC Field | Value | Language |
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dc.contributor.author | 허지혜 | - |
dc.contributor.author | 강은석 | - |
dc.contributor.author | 김다함 | - |
dc.contributor.author | 이병완 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 차봉수 | - |
dc.contributor.author | 김광준 | - |
dc.date.accessioned | 2014-12-19T16:41:47Z | - |
dc.date.available | 2014-12-19T16:41:47Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0300-0664 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90017 | - |
dc.description.abstract | OBJECTIVE: Although glycated haemoglobin (A1c) levels are similar among patients with type 2 diabetes, the glycated albumin (GA)/A1c ratio varies considerably. On the basis of the hypothesis that endogenous insulin secretion might be correlated with the GA/A1c ratio, we investigated whether insulin secretory function or insulin resistance has different effects on the GA/A1c ratio in patients with type 2 diabetes using the standardized liquid meal test. DESIGN: A clinical, retrospective study. PATIENTS AND MEASUREMENTS: A total of 758 patients with type 2 diabetes ingested a standardized liquid meal (i.e. 500 kcal, 17·5 g fat, 68·5 g carbohydrate and 17·5 g protein). The subjects were divided into two groups: those with GA/A1c ratio <2·5 (n = 414) and those with GA/A1c ratio ≥2·5 (n = 344). We compared the A1c and GA levels, and the GA/A1c ratio and evaluated the relationships between the glycaemic indices and other parameters. Effects of β-cell function [homeostasis model assessment (HOMA-β), insulinogenic index (IGI)] and insulin resistance (HOMA-IR) on the GA/A1c ratio were also examined. RESULTS: The GA/A1c ratio was significantly correlated with HOMA-β, IGI and body mass index (BMI) but not with HOMA-IR. Furthermore, after adjusting for age, gender, BMI, haemoglobin and albumin levels, the GA/A1c ratio was still inversely correlated with both HOMA-β and IGI. CONCLUSIONS: The GA/A1c ratio is significantly correlated with insulin secretory function but not with insulin resistance. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CLINICAL ENDOCRINOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glycated Hemoglobin A/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin/secretion* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Serum Albumin/metabolism* | - |
dc.title | The ratio of glycated albumin to glycated haemoglobin correlates with insulin secretory function. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Daham Kim | - |
dc.contributor.googleauthor | Kwang J. Kim | - |
dc.contributor.googleauthor | Ji H. Huh | - |
dc.contributor.googleauthor | Byung-Wan Lee | - |
dc.contributor.googleauthor | Eun S. Kang | - |
dc.contributor.googleauthor | Bong S. Cha | - |
dc.contributor.googleauthor | Hyun C. Lee | - |
dc.identifier.doi | 22150917 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04368 | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A02796 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03996 | - |
dc.contributor.localId | A00363 | - |
dc.contributor.localId | A00317 | - |
dc.relation.journalcode | J00571 | - |
dc.identifier.eissn | 1365-2265 | - |
dc.identifier.pmid | 22150917 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2011.04312.x/abstract | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Glycated Hemoglobin A/metabolism* | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Insulin/secretion* | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Retrospective Studies | - |
dc.subject.keyword | Serum Albumin/metabolism* | - |
dc.contributor.alternativeName | Huh, Ji Hye | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Kim, Da Ham | - |
dc.contributor.alternativeName | Lee, Byung Wan | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Huh, Ji Hye | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Lee, Byung Wan | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Kim, Da Ham | - |
dc.contributor.affiliatedAuthor | Kim, Kwang Joon | - |
dc.citation.volume | 77 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 679 | - |
dc.citation.endPage | 683 | - |
dc.identifier.bibliographicCitation | CLINICAL ENDOCRINOLOGY, Vol.77(5) : 679-683, 2012 | - |
dc.identifier.rimsid | 32310 | - |
dc.type.rims | ART | - |
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