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Chemerin levels are positively correlated with abdominal visceral fat accumulation.

Authors
 Hyun-Young Shin  ;  Duk C. Lee  ;  Sang H. Chu  ;  Justin Y. Jeon  ;  Mi K. Lee  ;  Jee A. Im  ;  Ji W. Lee 
Citation
 Clinical Endocrinology, Vol.77(1) : 47-50, 2012 
Journal Title
 Clinical Endocrinology 
ISSN
 0300-0664 
Issue Date
2012
Abstract
OBJECTIVE: Chemerin, a recently discovered adipocytokine, may be linked to obesity and obesity-associated metabolic complications. However, the relationship between visceral fat accumulation and chemerin is still unknown. Therefore, we investigated the relationship between serum chemerin levels and body composition as measured by computed tomography (CT). PATIENTS: We recruited 173 men and women without histories of diabetes or cardiovascular disease. MEASUREMENTS: Biomarkers of metabolic risk factors and body composition by computed tomography were assessed. Serum chemerin levels were measured by enzyme-linked immunosorbent assay. RESULTS: Chemerin levels correlated with body mass index (BMI), waist circumference, abdominal visceral fat area, blood pressure, fasting insulin, homoeostasis model of assessment-insulin resistance, total cholesterol, triglyceride, creatinine, aspartate aminotransferase and alanine aminotransferase. By stepwise multiple regression analysis, abdominal visceral fat area, blood pressure and total cholesterol levels independently affected chemerin levels. CONCLUSIONS: Abdominal visceral fat accumulation, blood pressure and lipid profile were significantly associated with serum chemerin levels. Our findings suggest that chemerin may be a mediator that links visceral obesity to cardiovascular risk factors.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2011.04217.x/abstract
DOI
10.1111/j.1365-2265.2011.04217.x
Appears in Collections:
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
이덕철(Lee, Duk Chul) ORCID logo https://orcid.org/0000-0001-9166-1813
이지원(Lee, Ji Won) ORCID logo https://orcid.org/0000-0002-2666-4249
추상희(Chu, Sang Hui) ORCID logo https://orcid.org/0000-0001-6877-5599
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90015
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