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Diagnostic utilities of procalcitonin and C-reactive protein for the prediction of bacteremia determined by blood culture.

Authors
 Seri Jeong  ;  Yongjung Park  ;  Yonggeun Cho  ;  Hyon-Suk Kim 
Citation
 CLINICA CHIMICA ACTA, Vol.413(21-22) : 1731-1736, 2012 
Journal Title
CLINICA CHIMICA ACTA
ISSN
 0009-8981 
Issue Date
2012
MeSH
Aged ; Area Under Curve ; Bacteremia/blood* ; Bacteremia/diagnosis ; Bacteriological Techniques ; C-Reactive Protein/analysis* ; Calcitonin/blood* ; Calcitonin Gene-Related Peptide ; Female ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Protein Precursors/blood* ; ROC Curve ; Retrospective Studies
Keywords
Bacteremia ; Blood culture ; Contamination ; C-reactive protein ; Procalcitonin
Abstract
BACKGROUND: We compared the diagnostic utilities of procalcitonin (PCT) and C-reactive protein (CRP) for predicting bacteremia diagnosed by blood cultures. PCT was also evaluated as a parameter for differentiating true bacteremia from culture contamination.

METHODS: We analyzed a total of 3343 patients in which PCT, CRP, and blood cultures were concurrently requested for detecting bacteremia from January 2010 to December 2011. PCT concentrations were measured by the VIDAS® Brahms PCT assay, and CRP concentrations were determined by a turbidimetric assay using CA-400 analyzer.

RESULTS: The PCT concentrations of bacteremia cases (n=331) were significantly higher than those of non-bacteremia (n=2856) (median: 3.2 ng/ml vs. 0.4 ng/ml, P<0.0001). The correlation coefficient between the PCT and CRP concentrations was 0.51. The areas under the receiver operating characteristic curves (ROC-AUCs) of PCT and CRP for discriminating bacteremia from non-bacteremia were 0.76 and 0.64, respectively. The ROC-AUC of PCT for differentiating true bacteremia from contamination was 0.86, while that of CRP was 0.65.

CONCLUSIONS: PCT concentration by single testing was more useful for predicting bacteremia than CRP. PCT also exhibited diagnostic utility for ruling out blood culture contamination. Thus, PCT could be helpful in the accurate diagnosis of bacteremia.
Full Text
http://www.sciencedirect.com/science/article/pii/S000989811200335X
DOI
22759977
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Cho, Yonggeun(조용근) ORCID logo https://orcid.org/0000-0003-1946-4318
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89983
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