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The association between pentraxin 3 and insulin resistance in obese children at baseline and after physical activity intervention.

 Sang Hui Chu ; Ji-Hye Park ; Justin Y. Jeon ; Young-Bum Kim ; Kyong-Mee Chung ; Ji Won Lee ; Choon Hee Chung ; Deok Kong ; Jee-Aee Im ; Masayo Naruse ; Eun Sung Kim ; Dong Hoon Lee ; Jae Youn Chung ; Ki Yong Ahn ; Yoonsuk Jekal ; Mi Kyung Lee 
 Clinica Chimica Acta, Vol.413(19-20) : 1430~1437, 2012 
Journal Title
 Clinica Chimica Acta 
Issue Date
BACKGROUND: The role of pentraxin-3 (PTX3) in the development of insulin resistance is still not clear. We aimed to test 1) whether circulating PTX3 levels are associated with insulin resistance and 2) whether changes in PTX3 levels after the physical activity are associated with changes in insulin resistance. METHODS: Fifty-seven overweight or obese children (39 boys, 18 girls; age: 12.04±0.82y, BMI: 26.5±1.2 kg/m²) participated in the study. All participants were housed together and their amount of physical activity (1823.5±1.34 kcal/day) and food intake (1882±68.8 kcal/day) were tightly controlled. RESULTS: Circulating PTX3 levels at baseline were negatively associated with fasting insulin (r=-.336, p=0.012) and homeostasis model assessment of insulin resistance (HOMA-IR) (r=-.334, p=0.014) even after adjustment for BMI and Tanner stage. The degree of change in PTX3 levels notably associated with changes in fasting insulin (r=-.280, p=0.035) and HOMA-IR (r=-.281, p=.034) in response to the physical activity intervention. Subgroup analysis further indicates that HOMA-IR was improved more in subjects whose PTX3 levels were increased compared with subjects who PTX3 levels were decreased (HOMA-IR delta: -2.33±1.3 vs -1.46±0.70, p=0.004). CONCLUSION: PTX3 is negatively associated with insulin resistance and associated with changes in insulin resistance induced by physical activity in overweight and obese children.
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1. 연구논문 > 1. College of Medicine > Dept. of Family Medicine
1. 연구논문 > 3. College of Nursing > Dept. of Nursing Environment Systems
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