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Serum ferritin level is associated with the prevalence of metabolic syndrome in Korean adults: the 2007-2008 Korean National Health and Nutrition Examination Survey.

Authors
 Hee-Taik Kang  ;  John A. Linton  ;  Jae-Yong Shim 
Citation
 CLINICA CHIMICA ACTA, Vol.413(5-6) : 636-641, 2012 
Journal Title
 CLINICA CHIMICA ACTA 
ISSN
 0009-8981 
Issue Date
2012
MeSH
Adult ; Female ; Ferritins/blood* ; Health Surveys ; Humans ; Male ; Metabolic Syndrome/blood* ; Metabolic Syndrome/epidemiology ; Middle Aged ; Republic of Korea/epidemiology
Keywords
Ferritin ; Insulin resistance ; Inflammation ; Oxidative stress ; Metabolic syndrome
Abstract
BACKGROUND: Increased ferritin concentrations, which reflect body iron stores, contribute to insulin dysfunction and metabolic syndrome (MetS). METHODS: This cross-sectional study included 7346 subjects (3229 men and 4117 women) who participated in the 2007-2008 Korean National Health and Nutrition Examination Survey (KNHANES). We adopted the modified Asian criteria for MetS from the American Heart Association/National Heart, Lung, and Blood Institute. RESULTS: In comparison with participants in the first serum ferritin quartile, the odds ratio (95% confidence interval) for MetS for participants in the fourth serum ferritin quartile was 1.67 (1.24-2.23) in men and 1.41 (1.06-1.88) in women after adjusting for multiple covariates (including menopausal status in women) except insulin resistance. This association was attenuated, however, after additionally adjusting for insulin resistance [1.46 (1.08-1.98) in men and 1.22 (0.91-1.65) in women]. In particular, higher serum ferritin concentrations were associated with increased triglyceride concentrations in men and glucose intolerance in women. CONCLUSIONS: Increased serum ferritin level was positively associated with the prevalence of MetS and with some diagnostic components of MetS, i.e., we found that increased serum ferritin concentrations were associated with high triglyceride and glucose concentrations in men and women, respectively.
Full Text
http://www.sciencedirect.com/science/article/pii/S0009898111006917
DOI
22212623
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hee Taik(강희택)
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Linton, John A.(인요한) ORCID logo https://orcid.org/0000-0001-8000-3049
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89975
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