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Inhibition of Akt/FOXO3a signaling by constitutively active FOXO3a suppresses growth of follicular thyroid cancer cell lines.

Authors
 Zhen-Yu Hong  ;  Hyeon Jung Lee  ;  Dong Yeob Shin  ;  Suk Kyoung Kim  ;  MiRan Seo  ;  Eun Jig Lee 
Citation
 CANCER LETTERS, Vol.314(1) : 34-40, 2012 
Journal Title
 CANCER LETTERS 
ISSN
 0304-3835 
Issue Date
2012
MeSH
Adenocarcinoma, Follicular ; Adenoviridae/genetics ; Apoptosis ; Cell Cycle ; Cell Line, Tumor ; Cell Proliferation ; Forkhead Box Protein O3 ; Forkhead Transcription Factors/genetics* ; Genetic Therapy ; Humans ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors* ; Signal Transduction/physiology ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/therapy*
Keywords
FOXO3a ; Follicular thyroid cancer ; Gene therapy
Abstract
Akt-dependent FOXO3a cytoplasmic translocation is an important tumorigenic mechanism for escaping from apoptosis in cancer cells. In the present study, we examined whether non-phosphorylatable FOXO3a can inhibit cell growth of various follicular thyroid carcinoma (FTC) cell lines. Adenovirus carrying the FOXO3a-triple mutant (TM) sequence including point mutations at three Akt phosphorylation sites (Ad-FOXO3a-TM) was generated and transduced to the cells to mimic inhibition of Akt/FOXO3a signal. Transduction of Ad-FOXO3a-TM to FTC133 cells induced cell cycle arrest and apoptosis. Injection of Ad-FOXO3a-TM suppressed the growth of xenograft tumors in athymic mice. Consequently, our results indicate that gene therapy based on Ad-FOXO3a-TM has therapeutic potential for FTC.
Full Text
http://www.sciencedirect.com/science/article/pii/S0304383511005520
DOI
21974806
Appears in Collections:
5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Seo, Mi Ran(서미란)
Shin, Dong Yeob(신동엽) ORCID logo https://orcid.org/0000-0003-1048-7978
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
Lee, Hyeon Jeong(이현정) ORCID logo https://orcid.org/0000-0003-0635-5454
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/89867
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