Cited 13 times in
Inhibition of Akt/FOXO3a signaling by constitutively active FOXO3a suppresses growth of follicular thyroid cancer cell lines
DC Field | Value | Language |
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dc.contributor.author | 서미란 | - |
dc.contributor.author | 신동엽 | - |
dc.contributor.author | 이은직 | - |
dc.contributor.author | 이현정 | - |
dc.date.accessioned | 2014-12-19T16:37:04Z | - |
dc.date.available | 2014-12-19T16:37:04Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/89867 | - |
dc.description.abstract | Akt-dependent FOXO3a cytoplasmic translocation is an important tumorigenic mechanism for escaping from apoptosis in cancer cells. In the present study, we examined whether non-phosphorylatable FOXO3a can inhibit cell growth of various follicular thyroid carcinoma (FTC) cell lines. Adenovirus carrying the FOXO3a-triple mutant (TM) sequence including point mutations at three Akt phosphorylation sites (Ad-FOXO3a-TM) was generated and transduced to the cells to mimic inhibition of Akt/FOXO3a signal. Transduction of Ad-FOXO3a-TM to FTC133 cells induced cell cycle arrest and apoptosis. Injection of Ad-FOXO3a-TM suppressed the growth of xenograft tumors in athymic mice. Consequently, our results indicate that gene therapy based on Ad-FOXO3a-TM has therapeutic potential for FTC. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CANCER LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma, Follicular | - |
dc.subject.MESH | Adenoviridae/genetics | - |
dc.subject.MESH | Apoptosis | - |
dc.subject.MESH | Cell Cycle | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Forkhead Box Protein O3 | - |
dc.subject.MESH | Forkhead Transcription Factors/genetics* | - |
dc.subject.MESH | Genetic Therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/antagonists & inhibitors* | - |
dc.subject.MESH | Signal Transduction/physiology | - |
dc.subject.MESH | Thyroid Neoplasms/pathology | - |
dc.subject.MESH | Thyroid Neoplasms/therapy* | - |
dc.title | Inhibition of Akt/FOXO3a signaling by constitutively active FOXO3a suppresses growth of follicular thyroid cancer cell lines | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) | - |
dc.contributor.googleauthor | Zhen-Yu Hong | - |
dc.contributor.googleauthor | Hyeon Jung Lee | - |
dc.contributor.googleauthor | Dong Yeob Shin | - |
dc.contributor.googleauthor | Suk Kyoung Kim | - |
dc.contributor.googleauthor | MiRan Seo | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.identifier.doi | 10.1016/j.canlet.2011.09.010 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01876 | - |
dc.contributor.localId | A02093 | - |
dc.contributor.localId | A03050 | - |
dc.relation.journalcode | J00448 | - |
dc.identifier.eissn | 1872-7980 | - |
dc.identifier.pmid | 21974806 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0304383511005520 | - |
dc.subject.keyword | FOXO3a | - |
dc.subject.keyword | Follicular thyroid cancer | - |
dc.subject.keyword | Gene therapy | - |
dc.contributor.alternativeName | Seo, Mi Ran | - |
dc.contributor.alternativeName | Shin, Dong Yeob | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Seo, Mi Ran | - |
dc.contributor.affiliatedAuthor | Shin, Dong Yeob | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jig | - |
dc.citation.volume | 314 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 34 | - |
dc.citation.endPage | 40 | - |
dc.identifier.bibliographicCitation | CANCER LETTERS, Vol.314(1) : 34-40, 2012 | - |
dc.identifier.rimsid | 31952 | - |
dc.type.rims | ART | - |
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