토끼 두개골 모델에서 탈회동종골, 탈회우골, 및 합성 Hydroxyapatite의 골재생 비교연구

Abstract

The purpose of this study was to compare bone regenerative effects of allograft, xenograft, and alloplast bone substitutes in rabbit calvarial defects. 14 male New Zealand rabbits were used. Four defects with a diameter of 8 mm were created on each animal. Demineralized bone matrix (DBM) gel, bovine bone (BB) and hydroxyapatite (HA) were used as the three test groups, while the control group was left unfilled. The animals were sacrificed after 2 and 8 weeks of healing. All experimental groups at 8 weeks showed statistically significant differences in new bone formation compared 2 weeks. Residual biomaterials in sites received DBM gel decreased compared to the sites received BB and HA. Within the limits of this study, there were no significant differences in bone regeneration between the sites received DBM gel, BB, and HA.