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The promotion of cardiogenic differentiation of hMSCs by targeting epidermal growth factor receptor using microRNA-133a

 Se-Yeon Lee  ;  Onju Ham  ;  Min-Ji Cha  ;  Byeong-Wook Song  ;  Eunmi Choi  ;  Il-Kwon Kim  ;  Woochul Chang  ;  Soyeon Lim  ;  Chang Youn Lee  ;  Jun-Hee Park  ;  Jiyun Lee  ;  Yoonjin Bae  ;  Hyang-Hee Seo  ;  Eunhyun Choi  ;  Yangsoo Jang  ;  Ki-Chul Hwang 
 Biomaterials, Vol.34(1) : 92-99, 2012 
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Human bone marrow-derived mesenchymal stem cells (hMSCs) are an attractive candidate for cell therapy in heart disease. Low survival and incomplete electromechanical integration between resident cardiomyocytes and transplanted hMSCs remain unsolved. In order for an infarcted heart to tolerate transplantation, differentiation capacity in stem cells must be reinforced. In this study, we found that compound 56, an epidermal growth factor receptor (EGFR) inhibitor, promotes cardiogenic differentiation of hMSCs and the transplantation of hMSCs treated with compound 56 resulted in enhancement of heart functions. Furthermore, hMSCs transfected with microRNA-133a (miR-133a), which targets EGFR, were observed to express cardiac-specific markers. We also discovered that luciferase activity is exclusively decreased by targeting EGFR in hMSCs transfected with miR-133a mimic. These results suggest that EGFR plays a key role in the regulation of cardiogenic differentiation in hMSCs.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers
Yonsei Authors
김일권(Kim, Il Kwon)
박준희(Park, Jun-Hee)
배윤진(Bae, Yoon Jin)
서향희(Seo, Hyang Hee)
송병욱(Song, Byeong Wook)
이세연(Lee, Se Yeon)
이지윤(Lee, Ji Yun)
이창연(Lee, Chang Yeon)
임소연(Lim, So Yeon)
장양수(Jang, Yang Soo) ORCID logo https://orcid.org/0000-0002-2169-3112
차민지(Cha, Min Ji)
최은미(Choi, Eun Mi)
최은현(Choi, Eun Hyun)
함온주(Ham, On Ju)
황기철(Hwang, Ki Chul)
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